caa a22 4500 445330627 CHVBK 20180317142736.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10689-010-9391-0 doi (NATIONALLICENCE)springer-10.1007/s10689-010-9391-0 Genetic epidemiological analysis reveals a multi-gene additive model for gastric cancer [Elektronische Daten] [Sanyou Gao, Xiaohui Zhang, Peng Wang, Liping Dai, Jianying Zhang, Kaijuan Wang] A genetic epidemiologic analysis of gastric cancer in the Chinese Han population was conducted for 64 pedigrees (902 individuals) with gastric cancer and controls obtained from the population after a census was carried out in August 2007. The heritability of gastric cancer was performed using the Falconer method and the complex segregation analysis was performed using the Statistical Analysis for Genetic Epidemiology (S.A.G.E.) SEGREG program. The heritability of gastric cancer in first- and second-degree relatives was 54.75% (95% CI, 48.01-61.49%) and 44.97% (95% CI, 33.12-56.82%), respectively. The estimated segregation ratio of gastric cancer was 0.039 (95% CI, 0.017-0.061). The complex segregation analysis showed that the Mendelian inheritance of additive model provided the best fit to the data (AIC=170.58, P>0.05). Therefore, polygenetic or multi-factorial additive inheritance is involved in the genetic predisposition for the development of gastric cancer. Springer Science+Business Media B.V., 2010 Gastric cancer nationallicence Genetic epidemiology nationallicence Genetic model nationallicence Segregation analysis nationallicence Heritability nationallicence S.A.G.E : Statistical analysis for genetic epidemiology nationallicence OR : Odds ratio nationallicence 95%CI : 95% confidence intervals nationallicence SD : Standard deviation nationallicence H. pylori : Helicobacter pylori nationallicence h 2 : Heritability nationallicence P LM : Segregation ratio nationallicence LnL : Natural log likelihood nationallicence AIC : Akaike's information criterion nationallicence Gao Sanyou Henan Center for Disease Control and Prevention, 450016, Zhengzhou, China aut Zhang Xiaohui Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut Wang Peng Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut Dai Liping Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut Zhang Jianying Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut Wang Kaijuan Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut Familial Cancer Springer Netherlands 10/1(2011-03-01), 119-125 1389-9600 10:1<119 2011 10 10689 https://doi.org/10.1007/s10689-010-9391-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-010-9391-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gao Sanyou Henan Center for Disease Control and Prevention, 450016, Zhengzhou, China aut NATIONALLICENCE 700 1- Zhang Xiaohui Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Wang Peng Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Dai Liping Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Zhang Jianying Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Wang Kaijuan Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Ave, 450001, Zhengzhou, China aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/1(2011-03-01), 119-125 1389-9600 10:1<119 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer