caa a22 4500 445330651 CHVBK 20180317142736.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10689-010-9388-8 doi (NATIONALLICENCE)springer-10.1007/s10689-010-9388-8 Hereditary prostate cancer as a feature of Lynch Syndrome [Elektronische Daten] [Christina Bauer, Anna Ray, Bronwen Halstead-Nussloch, Robert Dekker, Victoria Raymond, Stephen Gruber, Kathleen Cooney] Lynch Syndrome is an autosomal dominant condition characterized by early onset colorectal cancer (CRC) and is associated with cancers of the gastrointestinal and reproductive tracts. Germline mutations in DNA mismatch repair (MMR) genes have been causally associated with cancers of Lynch Syndrome. We investigated the occurrence of prostate cancer (PCa) in families with a history of colorectal cancer to assess prostate cancer as a feature of the Lynch Syndrome spectrum. Family pedigrees containing at least one CRC case as well as those meeting guidelines for Lynch Syndrome were identified and tumors were requested from participants who underwent radical prostatectomy (RP). Selected families were analyzed for association with type of PCa and clinical characteristics of aggressive disease. Microsatellite Instability (MSI) analysis was preformed on available tumors and correlated to loss of expression in MMR genes by immunohistochemical (IHC) staining. 95 individuals were identified as members of potential Lynch Syndrome families who underwent RP and 35 tumors from 31 families were received for MSI analysis. Two tumors from two unrelated families with known MMR mutations were MSI-high and one additional case from a third family was MSI-low. The remainder of the prostate cancer cases demonstrated no evidence of MSI. PCa incidence in families enriched for hereditary PCa with a history of Lynch Syndrome cancers is not strongly suggestive of the presence of an MMR mutation. However prostate tumors in known MMR mutation carriers did display MSI and loss of gene expression suggesting that PCa may arise in Lynch Syndrome due to defective DNA mismatch repair. Springer Science+Business Media B.V., 2010 Lynch Syndrome nationallicence Prostate cancer nationallicence MMR mutations nationallicence Microsatellite instability nationallicence Bauer Christina Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA aut Ray Anna Department of Internal Medicine, University of Michigan Medical School, 7216 CC, SPC 5948, 1500 East Medical Center Drive, 48109-5948, Ann Arbor, MI, USA aut Halstead-Nussloch Bronwen Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA aut Dekker Robert Department of Internal Medicine, University of Michigan Medical School, 7216 CC, SPC 5948, 1500 East Medical Center Drive, 48109-5948, Ann Arbor, MI, USA aut Raymond Victoria Department of Internal Medicine, University of Michigan Medical School, 7216 CC, SPC 5948, 1500 East Medical Center Drive, 48109-5948, Ann Arbor, MI, USA aut Gruber Stephen Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA aut Cooney Kathleen Department of Internal Medicine, University of Michigan Medical School, 7216 CC, SPC 5948, 1500 East Medical Center Drive, 48109-5948, Ann Arbor, MI, USA aut Familial Cancer Springer Netherlands 10/1(2011-03-01), 37-42 1389-9600 10:1<37 2011 10 10689 https://doi.org/10.1007/s10689-010-9388-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-010-9388-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bauer Christina Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Ray Anna Department of Internal Medicine, University of Michigan Medical School, 7216 CC, SPC 5948, 1500 East Medical Center Drive, 48109-5948, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Halstead-Nussloch Bronwen Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Dekker Robert Department of Internal Medicine, University of Michigan Medical School, 7216 CC, SPC 5948, 1500 East Medical Center Drive, 48109-5948, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Raymond Victoria Department of Internal Medicine, University of Michigan Medical School, 7216 CC, SPC 5948, 1500 East Medical Center Drive, 48109-5948, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Gruber Stephen Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Cooney Kathleen Department of Internal Medicine, University of Michigan Medical School, 7216 CC, SPC 5948, 1500 East Medical Center Drive, 48109-5948, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/1(2011-03-01), 37-42 1389-9600 10:1<37 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer