caa a22 4500 445330716 CHVBK 20180317142736.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10689-010-9400-3 doi (NATIONALLICENCE)springer-10.1007/s10689-010-9400-3 Strictly defined familial male breast cancer [Elektronische Daten] [Uwe Güth, Dieter Müller, Dorothy Huang, Ellen Obermann, Hansjakob Müller] The term "familial male breast cancer” is often misleading, because in the breast cancer families reported in the literature, the vast majority of the patients were women and only a few were men. In this report, we present the rare case of a strictly defined familial male breast cancer (MBC) in which exclusively men were diagnosed with breast cancer. Three of four brothers developed the disease between the age of 46 and 64years within a period of 21years whereas all female relatives remained unaffected. The three affected men did not show the typical known clinical and genetic risk factors for MBC. An X-linked recessive inheritance may be possible in these cases. One way to potentially improve the identification of the causes of MBC could be a through a strictly studying families in which the male members were exclusively diagnosed with this malignancy. This approach emphasizes familial MBC as a distinct entity and not only as a variant of female breast cancer. Springer Science+Business Media B.V., 2010 Familial breast cancer nationallicence Male breast cancer nationallicence Risk factor nationallicence Genetic susceptibility nationallicence BRCA2 nationallicence Güth Uwe Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland aut Müller Dieter Müller & Hess, Practice for Gynecology, Bahnhofstrasse 25, 4133, Pratteln, Switzerland aut Huang Dorothy Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland aut Obermann Ellen Institute of Pathology, University of Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland aut Müller Hansjakob Division of Medical Genetics (UKBB/DBM), University of Basel, Römergasse 5, 4005, Basel, Switzerland aut Familial Cancer Springer Netherlands 10/1(2011-03-01), 73-77 1389-9600 10:1<73 2011 10 10689 https://doi.org/10.1007/s10689-010-9400-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-010-9400-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Güth Uwe Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland aut NATIONALLICENCE 700 1- Müller Dieter Müller & Hess, Practice for Gynecology, Bahnhofstrasse 25, 4133, Pratteln, Switzerland aut NATIONALLICENCE 700 1- Huang Dorothy Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland aut NATIONALLICENCE 700 1- Obermann Ellen Institute of Pathology, University of Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland aut NATIONALLICENCE 700 1- Müller Hansjakob Division of Medical Genetics (UKBB/DBM), University of Basel, Römergasse 5, 4005, Basel, Switzerland aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/1(2011-03-01), 73-77 1389-9600 10:1<73 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer