caa a22 4500 445330732 CHVBK 20180317142736.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10689-011-9452-z doi (NATIONALLICENCE)springer-10.1007/s10689-011-9452-z The sex ratio and age of onset features of gastric cancer patients in hereditary diffuse gastric cancer families [Elektronische Daten] [Junxiu Yu, Zhenfang Li] An understanding of the clinical features of gastric cancer (GC) in hereditary diffuse gastric cancer (HDGC) families may be helpful in deciding who should receive prophylactic total gastrectomy and when. This study evaluates the sex ratio and age of onset features of these patients. Forty-seven HDGC families were screened from the English (40 families), Chinese (7 families) literature. One family was ascertained in our hospital. A total of 48 HDGC families with 192 GC cases were analyzed. The patients were grouped as Asian and non-Asian cases according the first author corresponding address. The male to female ratio of GC patients in our study was less than general GC population (0.769 vs. 1.826, P<0.0001). The mean age of male cases was higher than that for females (48.9 vs. 43.1years; P=0.012). The mean age for parents of cases was higher than that for the offspring of cases (52.5 vs. 37.4years; P=0.0001). There was a significant age correlation between sib-sib GC pairs (P<0.0001). The male to female ratio of Asian GC patients was higher than that of non-Asian GC cases (1.450 vs. 0.614, P=0.01). The age for Asian GC patients was higher than that of non-Asian GC patients (52.1 vs. 43.5years, P=0.001). The results showed that female GC patients were more frequent and younger than male patients in HDGC families. The parents of cases were older than offspring cases. There was a significant age correlation between sib-sib cases. There was regional disparity in the sex ratio and age features. Springer Science+Business Media B.V., 2011 Stomach neoplasms nationallicence Hereditary nationallicence Sex ratio nationallicence Age of onset nationallicence Parents nationallicence Offspring nationallicence Siblings nationallicence Correlation nationallicence Yu Junxiu Department of Gastrointestinal Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, 67, West Dongchang Road, 252000, Liaocheng, Shandong, China aut Li Zhenfang Department of Gastroenterology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, China aut Familial Cancer Springer Netherlands 10/3(2011-09-01), 573-579 1389-9600 10:3<573 2011 10 10689 https://doi.org/10.1007/s10689-011-9452-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9452-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yu Junxiu Department of Gastrointestinal Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, 67, West Dongchang Road, 252000, Liaocheng, Shandong, China aut NATIONALLICENCE 700 1- Li Zhenfang Department of Gastroenterology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, China aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/3(2011-09-01), 573-579 1389-9600 10:3<573 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer