caa a22 4500 445330740 CHVBK 20180317142736.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10689-011-9448-8 doi (NATIONALLICENCE)springer-10.1007/s10689-011-9448-8 Attitudes toward childbearing and prenatal testing in individuals undergoing genetic testing for Lynch Syndrome [Elektronische Daten] [Akriti Dewanwala, Anu Chittenden, Margery Rosenblatt, Rowena Mercado, Judy Garber, Sapna Syngal, Elena Stoffel] To examine attitudes toward childbearing and prenatal genetic testing among individuals at risk for Lynch Syndrome (LS), the most common type of hereditary colorectal cancer. Individuals undergoing clinical genetic testing for mismatch repair (MMR) gene mutations completed written questionnaires before and after testing. 161 of 192 (84%) eligible individuals participated in the study. Mean age was 46years (range 20-75), 71% were female, 53% had a personal diagnosis of cancer, and 68% had children. Eighty percent worried about their children's risk for developing cancer; however only 9% reported their decision to have children was affected by their family history of cancer. When asked whether providing prenatal testing to carriers of MMR gene mutations was ethical, 66% (86/130) of respondents agreed/strongly agreed, 25% (32) were neutral and 9% (12) disagreed/strongly disagreed. Of 48 individuals planning to have children in the future, 57% (27) intended to have children regardless of their genetic test result. If found to carry a MMR gene mutation that confirmed LS, 42% (20) would consider prenatal testing for a future pregnancy and 20% (7/35) of women would consider having children earlier in order to have prophylactic surgery to reduce their risk for gynecologic cancers. Individuals undergoing genetic testing for LS may utilize test results to make reproductive decisions. Clinicians should be prepared to discuss options of reproductive genetic technologies during counseling of LS patients of childbearing age. Springer Science+Business Media B.V., 2011 Lynch syndrome nationallicence Prenatal testing nationallicence Preimplantation genetic diagnosis nationallicence Family nationallicence Genetic testing nationallicence Genetic counseling nationallicence Dewanwala Akriti Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut Chittenden Anu Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut Rosenblatt Margery Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut Mercado Rowena Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut Garber Judy Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut Syngal Sapna Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut Stoffel Elena Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut Familial Cancer Springer Netherlands 10/3(2011-09-01), 549-556 1389-9600 10:3<549 2011 10 10689 https://doi.org/10.1007/s10689-011-9448-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9448-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dewanwala Akriti Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut NATIONALLICENCE 700 1- Chittenden Anu Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut NATIONALLICENCE 700 1- Rosenblatt Margery Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut NATIONALLICENCE 700 1- Mercado Rowena Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut NATIONALLICENCE 700 1- Garber Judy Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut NATIONALLICENCE 700 1- Syngal Sapna Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut NATIONALLICENCE 700 1- Stoffel Elena Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/3(2011-09-01), 549-556 1389-9600 10:3<549 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer