caa a22 4500 445330759 CHVBK 20180317142736.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10689-011-9440-3 doi (NATIONALLICENCE)springer-10.1007/s10689-011-9440-3 Management of renal tumors in Von Hippel-Lindau disease by percutaneous CT fluoroscopic guided radiofrequency ablation: preliminary results [Elektronische Daten] [Yoichi Iwamoto, Hideki Kanda, Koichiro Yamakado, Norihito Soga, Kiminobu Arima, Kan Takeda, Yoshiki Sugimura] We evaluated the feasibility and safety of percutaneous radiofrequency (RF) ablation of renal cell carcinomas (RCCs) in patients with Von Hippel-Lindau (VHL) disease. A total of 12 RCCs were treated by RF ablation in 7 patients with VHL disease. RF electrodes were placed under CT fluoroscopic guidance with conscious sedation. Technical success, technical effectiveness (disappearance of tumor enhancement), local tumor progression, complications and change in the estimated glomerular filtration rate (eGFR) were evaluated. A total of 9 sessions were undertaken. All procedures were performed with a planned protocol with a technical success rate of 100%. Tumor enhancement disappeared in all 12 tumors indicating a technical effectiveness rate of 100%. Local tumor progression was not found in any patient during the mean follow-up of 22±11months (range 12-46months). There were no complications related to the RF procedures. The mean eGFR decreased from 65.3±10.9ml/min (range 48.5-77.5ml/min) to 60.3±11.3ml/min (range, 45.8-73.4ml/min, P<0.03). The mean percentage decrease in eGFR after the last ablation was 7.6% (range 0-21.6%). Renal RF ablation is a safe and effective treatment for renal tumours that may allow patients with VHL disease to avoid major surgical interventions. Springer Science+Business Media B.V., 2011 Radiofrequency ablation nationallicence Von Hippel-Lindau disease nationallicence Renal cell carcinoma nationallicence RCCs : Renal cell carcinomas nationallicence CNS : Central nervous system nationallicence RF : Renal radiofrequency nationallicence CT : Computed tomography nationallicence eGFR : Estimated glomerular filtration rate nationallicence VHL : Von Hippel-Lindau nationallicence Iwamoto Yoichi Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Kanda Hideki Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Yamakado Koichiro Department of Radiology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Soga Norihito Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Arima Kiminobu Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Takeda Kan Department of Radiology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Sugimura Yoshiki Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Familial Cancer Springer Netherlands 10/3(2011-09-01), 529-534 1389-9600 10:3<529 2011 10 10689 https://doi.org/10.1007/s10689-011-9440-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9440-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iwamoto Yoichi Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Kanda Hideki Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Yamakado Koichiro Department of Radiology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Soga Norihito Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Arima Kiminobu Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Takeda Kan Department of Radiology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Sugimura Yoshiki Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/3(2011-09-01), 529-534 1389-9600 10:3<529 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer