caa a22 4500 445330775 CHVBK 20180317142736.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10689-011-9457-7 doi (NATIONALLICENCE)springer-10.1007/s10689-011-9457-7 The LKB1 complex-AMPK pathway: the tree that hides the forest [Elektronische Daten] [Michaël Sebbagh, Sylviane Olschwang, Marie-Josée Santoni, Jean-Paul Borg] Initially identified as the Caenorhabditis elegans PAR-4 homologue, the serine threonine kinase LKB1 is conserved throughout evolution and ubiquitously expressed. In humans, LKB1 is causally linked to the Peutz-Jeghers syndrome and is one of the most commonly mutated genes in several cancers like lung and cervical carcinomas. These observations have led to classify LKB1 as tumour suppressor gene. Although, considerable dark zones remain, an impressive leap in the understanding of LKB1 functions has been done during the last decade. Role of LKB1 as a major actor of the AMPK/mTOR pathway connecting cellular metabolism, cell growth and tumorigenesis has been extensively studied probably to the detriment of other functions of equal importance. This review will discuss about LKB1 activity regulation, its effectors and clues on their involvement in cell polarity. Springer Science+Business Media B.V., 2011 Peutz-Jeghers syndrome nationallicence Lkb1 nationallicence Regulation nationallicence AMPK-related kinases nationallicence Cell polarity nationallicence Sebbagh Michaël Inserm, U891, Centre de Recherche en Cancérologie de Marseille, 27 Blv Lei Roure, 13009, Marseille, France aut Olschwang Sylviane Inserm, U891, Centre de Recherche en Cancérologie de Marseille, 27 Blv Lei Roure, 13009, Marseille, France aut Santoni Marie-Josée Inserm, U891, Centre de Recherche en Cancérologie de Marseille, 27 Blv Lei Roure, 13009, Marseille, France aut Borg Jean-Paul Inserm, U891, Centre de Recherche en Cancérologie de Marseille, 27 Blv Lei Roure, 13009, Marseille, France aut Familial Cancer Springer Netherlands 10/3(2011-09-01), 415-424 1389-9600 10:3<415 2011 10 10689 https://doi.org/10.1007/s10689-011-9457-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9457-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sebbagh Michaël Inserm, U891, Centre de Recherche en Cancérologie de Marseille, 27 Blv Lei Roure, 13009, Marseille, France aut NATIONALLICENCE 700 1- Olschwang Sylviane Inserm, U891, Centre de Recherche en Cancérologie de Marseille, 27 Blv Lei Roure, 13009, Marseille, France aut NATIONALLICENCE 700 1- Santoni Marie-Josée Inserm, U891, Centre de Recherche en Cancérologie de Marseille, 27 Blv Lei Roure, 13009, Marseille, France aut NATIONALLICENCE 700 1- Borg Jean-Paul Inserm, U891, Centre de Recherche en Cancérologie de Marseille, 27 Blv Lei Roure, 13009, Marseille, France aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/3(2011-09-01), 415-424 1389-9600 10:3<415 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer