caa a22 4500 445330856 CHVBK 20180317142736.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10689-011-9437-y doi (NATIONALLICENCE)springer-10.1007/s10689-011-9437-y Serum levels of IGF-I and BRCA penetrance: a case control study in breast cancer families [Elektronische Daten] [Patrizia Pasanisi, Eleonora Bruno, Elisabetta Venturelli, Siranoush Manoukian, Monica Barile, Bernard Peissel, Clelia De Giacomi, Bernardo Bonanni, Jacopo Berrino, Franco Berrino] High serum levels of insulin-like growth factor I (IGF-I) are associated with an increased risk of sporadic breast cancer (BC). The aim of the present work is to evaluate the association between IGF-I and hereditary BC risk, using a case-control approach. The work represents an "ad interim” cross-sectional analysis of an ongoing study with a prospective design whose aim is to recruit a cohort of women belonging to high genetic risk families to test potential modulators of penetrance and prognosis. The odd of exposure to high serum IGF-I levels among women with a previous diagnosis of BC ("cases”) was compared with the odd among unaffected "controls”. The odds ratio (OR) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression, controlling for confounders. We analysed 308 women (209 cases and 99 controls) at high genetic risk of BC. The adjusted OR of BC for the upper tertile of serum IGF-I versus the lowest one was 3.5 (95%CI 1.4-8.8). Excluding from the analysis 64 women under current Tamoxifen or GnRH analogues treatment, the adjusted OR of BC became 3.7 (95%CI 1.4-9.9). The association became stronger restricting the analysis to the 161 women (97 cases and 64 controls) with a proven BRCA mutation. If confirmed by a prospective approach, the association between IGF-I and familial BC will open further options for reducing BC risk in susceptible women. Springer Science+Business Media B.V., 2011 IGF-I nationallicence BRCA genes nationallicence Penetrance nationallicence Breast cancer nationallicence Primary prevention nationallicence Pasanisi Patrizia Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut Bruno Eleonora Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut Venturelli Elisabetta Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut Manoukian Siranoush Medical Genetics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut Barile Monica Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy aut Peissel Bernard Medical Genetics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut De Giacomi Clelia Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy aut Bonanni Bernardo Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy aut Berrino Jacopo Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut Berrino Franco Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut Familial Cancer Springer Netherlands 10/3(2011-09-01), 521-528 1389-9600 10:3<521 2011 10 10689 https://doi.org/10.1007/s10689-011-9437-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9437-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pasanisi Patrizia Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Bruno Eleonora Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Venturelli Elisabetta Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Manoukian Siranoush Medical Genetics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Barile Monica Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy aut NATIONALLICENCE 700 1- Peissel Bernard Medical Genetics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut NATIONALLICENCE 700 1- De Giacomi Clelia Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy aut NATIONALLICENCE 700 1- Bonanni Bernardo Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy aut NATIONALLICENCE 700 1- Berrino Jacopo Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Berrino Franco Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/3(2011-09-01), 521-528 1389-9600 10:3<521 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer