caa a22 4500 445330961 CHVBK 20180317142737.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10689-011-9441-2 doi (NATIONALLICENCE)springer-10.1007/s10689-011-9441-2 LKB1 signaling in advancing cell differentiation [Elektronische Daten] [Lina Udd, Tomi Mäkelä] The Peutz-Jeghers syndrome (PJS) culprit kinase LKB1 phosphorylates and activates multiple intracellular kinases regulating cell metabolism and polarity. The relevance of each of these pathways is highly variable depending on the tissue type, but typically represents functions of differentiated cells. These include formation and maintenance of specialized cell compartments in nerve axons, swift refunneling of metabolites and restructuring of cell architecture in response to environmental cues in committed lymphocytes, and ensuring energy-efficient oxygen-based energy expenditure. Such features are often lost or reduced in cancer cells, and indeed LKB1 defects in PJS-associated and sporadic cancers and even the benign PJS polyps lead to differentiation defects, including expansion of partially differentiated epithelial cells in PJS polyps and epithelial-to-mesenchymal transition in carcinomas. This review focuses on the involvement of LKB1 in the differentiation of epithelial, mesenchymal, hematopoietic and germinal lineages. Springer Science+Business Media B.V., 2011 LKB1 nationallicence STK11 nationallicence Differentiation nationallicence Peutz-Jeghers syndrome nationallicence Udd Lina Institute of Biotechnology and Genome-Scale Biology Research Program, University of Helsinki, P.O. Box 56 (Biocenter 1), 00014, Helsinki, Finland aut Mäkelä Tomi Institute of Biotechnology and Genome-Scale Biology Research Program, University of Helsinki, P.O. Box 56 (Biocenter 1), 00014, Helsinki, Finland aut Familial Cancer Springer Netherlands 10/3(2011-09-01), 425-435 1389-9600 10:3<425 2011 10 10689 https://doi.org/10.1007/s10689-011-9441-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9441-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Udd Lina Institute of Biotechnology and Genome-Scale Biology Research Program, University of Helsinki, P.O. Box 56 (Biocenter 1), 00014, Helsinki, Finland aut NATIONALLICENCE 700 1- Mäkelä Tomi Institute of Biotechnology and Genome-Scale Biology Research Program, University of Helsinki, P.O. Box 56 (Biocenter 1), 00014, Helsinki, Finland aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/3(2011-09-01), 425-435 1389-9600 10:3<425 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer