caa a22 4500 44533097X CHVBK 20180317142737.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10689-011-9443-0 doi (NATIONALLICENCE)springer-10.1007/s10689-011-9443-0 Sanchez-Cespedes Montse Programa Epigenetica i Biologia del Cancer-PEBC, Institut Investigacions Biomediques Bellvitge (IDIBELL), Hospital Duran i Reynals, Av. Gran Via de l'Hospitalet, 199-203, 08907, Hospitalet de Llobregat-Barcelona, Spain aut The role of LKB1 in lung cancer [Elektronische Daten] [Montse Sanchez-Cespedes] In humans, the LKB1 gene is located on the short arm of chromosome 19, which is frequently deleted in lung tumors. Unlike most cancers of sporadic origin, in non-small cell lung cancer (NSCLC) nearly half of the tumors harbor somatic and homozygous inactivating mutations in LKB1. In NSCLC, LKB1 inactivation strongly predominates in adenocarcinomas from smokers and coexists with mutations at other important cancer genes, including KRAS and TP53. Remarkably, LKB1 alterations frequently occur simultaneously with inactivation at another important tumor suppressor gene, BRG1 (also called SMARCA4), which is also located on chromosome 19p. The present review considers the frequency and pattern of LKB1 mutations in lung cancer and the distinct biological pathways in which the LKB1 protein is involved in the development of this type of cancer. Finally, the possible clinical applications in cancer management, especially in lung cancer treatment, associated with the presence of absence of LKB1 are discussed. Springer Science+Business Media B.V., 2011 Lung cancer nationallicence LKB1 (or STK11 ) nationallicence Peutz-Jeghers nationallicence BRG1 nationallicence SMARCA4 nationallicence Familial Cancer Springer Netherlands 10/3(2011-09-01), 447-453 1389-9600 10:3<447 2011 10 10689 https://doi.org/10.1007/s10689-011-9443-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9443-0 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sanchez-Cespedes Montse Programa Epigenetica i Biologia del Cancer-PEBC, Institut Investigacions Biomediques Bellvitge (IDIBELL), Hospital Duran i Reynals, Av. Gran Via de l'Hospitalet, 199-203, 08907, Hospitalet de Llobregat-Barcelona, Spain aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/3(2011-09-01), 447-453 1389-9600 10:3<447 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer