caa a22 4500 445331089 CHVBK 20180317142737.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10689-011-9463-9 doi (NATIONALLICENCE)springer-10.1007/s10689-011-9463-9 The identification and management of hereditary diffuse gastric cancer in a large Jordanian family [Elektronische Daten] [Henry Lynch, Ibrahim Aldoss, Jane Lynch] The management of families with hereditary diffuse gastric cancer is challenging as screening for cancer in CDH1 mutation carriers is insufficiently sensitive and the commonly recommended option, prophylactic total gastrectomy, is associated with certain morbidity and even potential mortality. We describe the particular challenges associated with the diagnosis and management of a large Jordanian family with hereditary diffuse gastric cancer. A preliminary pedigree enabled DNA testing for CDH1 mutation, denoted as c.1137G→A, on 4 family members; all were identified as mutation carriers. A family information service was then conducted in Amman, Jordan, where 40 family members gathered and we provided education and counseling. Signed permission enabled DNA collection for CDH1 germline mutation studies. Non-attendees were contacted and provided detailed information. Twenty-three family members have been tested for CDH1; 13 were positive and 10 were negative. The proband, a CDH1 mutation carrier, has undergone successful prophylactic total gastrectomy. We are hopeful that this model can be repeated throughout Jordan as well as other emerging countries where knowledge and action about hereditary cancer is lacking. Springer Science+Business Media B.V., 2011 Cancer genetics nationallicence Cancer prevention nationallicence Family study nationallicence Gastrectomy nationallicence Gastric cancer nationallicence Hereditary cancer nationallicence Hereditary diffuse gastric cancer nationallicence Jordan nationallicence Stomach cancer nationallicence DGC : Diffuse gastric cancer nationallicence FIS : Family information service nationallicence HDGC : Hereditary diffuse gastric cancer nationallicence Lynch Henry Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, 68178, Omaha, NE, USA aut Aldoss Ibrahim Department of Internal Medicine, Creighton University, Omaha, NE, USA aut Lynch Jane Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, 68178, Omaha, NE, USA aut Familial Cancer Springer Netherlands 10/4(2011-12-01), 667-672 1389-9600 10:4<667 2011 10 10689 https://doi.org/10.1007/s10689-011-9463-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9463-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lynch Henry Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, 68178, Omaha, NE, USA aut NATIONALLICENCE 700 1- Aldoss Ibrahim Department of Internal Medicine, Creighton University, Omaha, NE, USA aut NATIONALLICENCE 700 1- Lynch Jane Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, 68178, Omaha, NE, USA aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/4(2011-12-01), 667-672 1389-9600 10:4<667 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer