caa a22 4500 445331119 CHVBK 20180317142737.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10689-011-9470-x doi (NATIONALLICENCE)springer-10.1007/s10689-011-9470-x Microsatellite instability analysis in uterine cavity washings as a screening tool for endometrial cancer in Lynch syndrome [Elektronische Daten] [Julie Bouquier, Hélène Blons, Céline Narjoz, Fabrice Lécuru, Pierre Laurent-Puig, Anne-Sophie Bats] Although patients with Lynch syndrome (LS) are at high risk of endometrial cancer, gynecologic screening has been poorly investigated and diagnostic value of current screening tests remains unclear. Microsatellite instability (MSI) phenotype is found in more than 90% of endometrial cancers developed in LS patients. Here we report the first two cases of unstable endometrial tumors with detection of MSI in uterine cavity washings cells. This new technique may be a promising screening tool in LS. Springer Science+Business Media B.V., 2011 Lynch syndrome nationallicence Endometrial cancer nationallicence Screening nationallicence Microsatellite instability analysis nationallicence HNPCC : Hereditary non polyposis colorectal cancer nationallicence LS : Lynch syndrome nationallicence MMR : Mismatch repair nationallicence MSI : Microsatellite instability nationallicence Bouquier Julie Université Paris Descartes, Paris, France aut Blons Hélène Université Paris Descartes, Paris, France aut Narjoz Céline Université Paris Descartes, Paris, France aut Lécuru Fabrice Université Paris Descartes, Paris, France aut Laurent-Puig Pierre Université Paris Descartes, Paris, France aut Bats Anne-Sophie Université Paris Descartes, Paris, France aut Familial Cancer Springer Netherlands 10/4(2011-12-01), 655-657 1389-9600 10:4<655 2011 10 10689 https://doi.org/10.1007/s10689-011-9470-x text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-011-9470-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bouquier Julie Université Paris Descartes, Paris, France aut NATIONALLICENCE 700 1- Blons Hélène Université Paris Descartes, Paris, France aut NATIONALLICENCE 700 1- Narjoz Céline Université Paris Descartes, Paris, France aut NATIONALLICENCE 700 1- Lécuru Fabrice Université Paris Descartes, Paris, France aut NATIONALLICENCE 700 1- Laurent-Puig Pierre Université Paris Descartes, Paris, France aut NATIONALLICENCE 700 1- Bats Anne-Sophie Université Paris Descartes, Paris, France aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/4(2011-12-01), 655-657 1389-9600 10:4<655 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer