caa a22 4500 445331283 CHVBK 20180317142738.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10689-010-9410-1 doi (NATIONALLICENCE)springer-10.1007/s10689-010-9410-1 Familial gastric cancer: update for practice management [Elektronische Daten] [Giovanni Corso, Daniele Marrelli, Franco Roviello] About 90% of gastric carcinoma presents a sporadic setting and only 10% shows a familial cluster; among this group, 1-3% are considered as hereditary syndromes, with a clear genetic pathway. The most important genetic mechanisms are associated with CDH1 germline mutations, causing the hereditary diffuse gastric cancer syndrome. Other inherited predispositions with gastric carcinoma are the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz-Jeghers syndromes. In this brief update, we described these principal hereditary syndromes offering a simple management to physicians where are these diseases diagnosed. Springer Science+Business Media B.V., 2010 E-cadherin nationallicence Mismatch repair genes nationallicence TP53 nationallicence STK11 nationallicence Corso Giovanni Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy aut Marrelli Daniele Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy aut Roviello Franco Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy aut Familial Cancer Springer Netherlands 10/2(2011-06-01), 391-396 1389-9600 10:2<391 2011 10 10689 https://doi.org/10.1007/s10689-010-9410-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-010-9410-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Corso Giovanni Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Marrelli Daniele Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Roviello Franco Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/2(2011-06-01), 391-396 1389-9600 10:2<391 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer