caa a22 4500 445331356 CHVBK 20180317142738.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10689-010-9413-y doi (NATIONALLICENCE)springer-10.1007/s10689-010-9413-y Case report: renal cell carcinoma segregating with a t(2;3)(q37.3;q13.2) chromosomal translocation in an Ashkenazi Jewish family [Elektronische Daten] [L. McKay, M. Frydenberg, L. Lipton, F. Norris, I. Winship] Chromosome translocations involving chromosome 3 have previously been associated with the development of renal cell carcinoma. In this report we describe an Ashkenazi Jewish family with a previously unreported balanced constitutional translocation (t(2;3)(q37.3;q13.2)) segregating with the development of clear cell renal carcinomata in three family members spanning two generations. We outline the difficulties with the clinical utility of this finding for genetic counselling and risk management strategies. We suggest that an additional renal cancer susceptibility gene may exist at 3q13.2, and review known breakpoints in the autosomes which are associated with clear cell renal cell carcinoma. Springer Science+Business Media B.V., 2010 Chromosome 3 translocation nationallicence Clear cell renal carcinoma nationallicence Hereditary cancer nationallicence McKay L. Cabrini Institute, 183 Wattletree Rd, 3045, Malvern, Victoria, Australia aut Frydenberg M. Department of Surgery, Monash University, Melbourne, Victoria, Australia aut Lipton L. St Frances Xavier Cabrini Hospital, Malvern, Victoria, Australia aut Norris F. Cytogenetics Laboratory, Victorian Clinical Genetics Service, Parkville, Victoria, Australia aut Winship I. The Royal Melbourne Hospital, Parkville, Victoria, Australia aut Familial Cancer Springer Netherlands 10/2(2011-06-01), 349-353 1389-9600 10:2<349 2011 10 10689 https://doi.org/10.1007/s10689-010-9413-y text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-010-9413-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McKay L. Cabrini Institute, 183 Wattletree Rd, 3045, Malvern, Victoria, Australia aut NATIONALLICENCE 700 1- Frydenberg M. Department of Surgery, Monash University, Melbourne, Victoria, Australia aut NATIONALLICENCE 700 1- Lipton L. St Frances Xavier Cabrini Hospital, Malvern, Victoria, Australia aut NATIONALLICENCE 700 1- Norris F. Cytogenetics Laboratory, Victorian Clinical Genetics Service, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Winship I. The Royal Melbourne Hospital, Parkville, Victoria, Australia aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/2(2011-06-01), 349-353 1389-9600 10:2<349 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer