caa a22 4500 445331364 CHVBK 20180317142738.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10689-010-9407-9 doi (NATIONALLICENCE)springer-10.1007/s10689-010-9407-9 The impact of cancer pathology confirmation on clinical management of a family history of cancer [Elektronische Daten] [E. Edwards, A. Lucassen] Regional cancer genetics services in the UK base many of their risk assessments on the careful evaluation of a family history of disease. The pathological details of cancers in relatives can help refine this risk assessment and alter subsequent management. By analysing a variety of medical records, we surveyed how often a reported family history was discrepant from that recorded in the records, and how often this impacted on surveillance recommendations. Our survey analysed pathology confirmation and risk assessment in families over a 7-month period of referrals. 839 cancers were reported and 476 were independently confirmed. The accuracy of a reported family history differed depending on the reported site of a cancer and on the degree of relationship to the patient. Whilst the majority of reported cancers (84%) were confirmed, a change in risk assessment through pathology confirmation resulted in altered management in 20% of all referrals. Springer Science+Business Media B.V., 2010 Family history cancer nationallicence Screening recommendations nationallicence Surveillance nationallicence Accuracy reporting nationallicence Breast cancer nationallicence Ovarian cancer nationallicence Colorectal cancer nationallicence Genetic testing nationallicence Edwards E. Wessex Clinical Genetics Service, Southampton, UK aut Lucassen A. Wessex Clinical Genetics Service, Southampton, UK aut Familial Cancer Springer Netherlands 10/2(2011-06-01), 373-380 1389-9600 10:2<373 2011 10 10689 https://doi.org/10.1007/s10689-010-9407-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10689-010-9407-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Edwards E. Wessex Clinical Genetics Service, Southampton, UK aut NATIONALLICENCE 700 1- Lucassen A. Wessex Clinical Genetics Service, Southampton, UK aut NATIONALLICENCE 773 0- Familial Cancer Springer Netherlands 10/2(2011-06-01), 373-380 1389-9600 10:2<373 2011 10 10689 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer