caa a22 4500 445332468 CHVBK 20180317142741.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10198-010-0253-3 doi (NATIONALLICENCE)springer-10.1007/s10198-010-0253-3 Largely ignored: the impact of the threshold value for a QALY on the importance of a transferability factor [Elektronische Daten] [Pepijn Vemer, Maureen Rutten-van Mölken] Recently, several checklists systematically assessed factors that affect the transferability of cost-effectiveness (CE) studies between jurisdictions. The role of the threshold value for a QALY has been given little consideration in these checklists, even though the importance of a factor as a cause of between country differences in CE depends on this threshold. In this paper, we study the impact of the willingness-to-pay (WTP) per QALY on the importance of transferability factors in the case of smoking cessation support (SCS). We investigated, for several values of the WTP, how differences between six countries affect the incremental net monetary benefit (INMB) of SCS. The investigated factors were demography, smoking prevalence, mortality, epidemiology and costs of smoking-related diseases, resource use and unit costs of SCS, utility weights and discount rates. We found that when the WTP decreased, factors that mainly affect health outcomes became less important and factors that mainly effect costs became more important. With a WTP below €1,000, the factors most responsible for between country differences in INMB were resource use and unit costs of SCS and the costs of smoking-related diseases. Utility values had little impact. At a threshold above €10,000, between country differences were primarily due to different discount rates, utility weights and epidemiology of smoking-related diseases. Costs of smoking-related diseases had little impact. At all thresholds, demography had little impact. We concluded that, when judging the transferability of a CE study, we should consider the between country differences in WTP threshold values. The Author(s), 2010 Multinational nationallicence Transferability nationallicence Threshold value nationallicence Smoking cessation nationallicence Willingness-to-pay nationallicence Cost-effectiveness nationallicence QALY nationallicence Vemer Pepijn Institute for Medical Technology Assessment (iMTA), Erasmus University, PO Box 1738, 3000 DR, Rotterdam, The Netherlands aut Rutten-van Mölken Maureen Institute for Medical Technology Assessment (iMTA), Erasmus University, PO Box 1738, 3000 DR, Rotterdam, The Netherlands aut The European Journal of Health Economics Springer-Verlag 12/5(2011-10-01), 397-404 1618-7598 12:5<397 2011 12 10198 https://doi.org/10.1007/s10198-010-0253-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10198-010-0253-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vemer Pepijn Institute for Medical Technology Assessment (iMTA), Erasmus University, PO Box 1738, 3000 DR, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Rutten-van Mölken Maureen Institute for Medical Technology Assessment (iMTA), Erasmus University, PO Box 1738, 3000 DR, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- The European Journal of Health Economics Springer-Verlag 12/5(2011-10-01), 397-404 1618-7598 12:5<397 2011 12 10198 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer