caa a22 4500 445332638 CHVBK 20180317142742.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1209-7 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1209-7 S100B Protein Expressions as an Independent Predictor of Early Relapse in UICC Stages II and III Colon Cancer Patients after Curative Resection [Elektronische Daten] [Chi-Ching Hwang, Han-Tan Chai, Hsin-Wei Chen, Hsiang-Lin Tsai, Chien-Yu Lu, Fang-Jung Yu, Ming-Yii Huang, Jaw-Yuan Wang] Background: S100 calcium-binding proteins such as S100B are elevated in primary malignant melanoma and are used as tumor markers for malignant melanoma and numerous other cancers. The purpose of this study was to identify the novel predictors of early relapse in UICC stages II and III colon cancer patients and thus to identify a subgroup of patients who are at high risk for postoperative early relapse. Methods: Clinicopathological factors and S100B expression by immunohistochemical staining were retrospectively analyzed in 357 postoperative UICC stages II and III colon cancer patients to determine the predictors of early relapse. Results: Of 357 patients, 114 patients developed postoperative relapse during the follow-up period. Among 114 relapsed colon cancer patients, postoperative early relapse and non-early relapse were found in 56 patients (49.1%) and 58 patients (50.9%), respectively. Multivariate Cox proportional hazards analysis revealed that the presence of vascular invasion (P=.025; hazard ratio [HR], 5.532; 95% confidence interval [95% CI], 1.985-14.729), high postoperative CEA levels (P=.019; HR, 6.845; 95% CI, 2.393-15.256), and S100B overexpression (P<.001; HR, 26.250; 95% CI, 7.463-96.804) were demonstrated to be independent predictors of postoperative early relapse. Furthermore, postoperative relapsed colon cancer patients with S100B overexpression were demonstrated to have significantly lower overall survival rates than those without S100B overexpression (P<.001). Conclusions: This study suggests that S100B protein expression is a crucial predictor of early relapse in UICC stages II and III postoperative colon cancer patients and thus could help to define patients with this tumor entity who would benefit from enhanced follow-up and therapeutic program(s). Society of Surgical Oncology, 2010 Hwang Chi-Ching Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Chai Han-Tan Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital—Kaohsiung Medical Center, College of Medicine, Chang Gung University, Kaohsiung, Taiwan aut Chen Hsin-Wei Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Tsai Hsiang-Lin Department of Emergency Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan aut Lu Chien-Yu Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut Yu Fang-Jung Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut Huang Ming-Yii Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut Wang Jaw-Yuan Cancer Center and Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 139-145 1068-9265 18:1<139 2011 18 10434 https://doi.org/10.1245/s10434-010-1209-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1209-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hwang Chi-Ching Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Chai Han-Tan Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital—Kaohsiung Medical Center, College of Medicine, Chang Gung University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Chen Hsin-Wei Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Tsai Hsiang-Lin Department of Emergency Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Lu Chien-Yu Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Yu Fang-Jung Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Huang Ming-Yii Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Wang Jaw-Yuan Cancer Center and Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 139-145 1068-9265 18:1<139 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer