caa a22 4500 445332700 CHVBK 20180317142742.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1206-x doi (NATIONALLICENCE)springer-10.1245/s10434-010-1206-x Lymph-Vascular Space Invasion as a Significant Risk Factor for Isolated Para-aortic Lymph Node Metastasis in Endometrial Cancer: A Study of 203 Consecutive Patients [Elektronische Daten] [Suk-Joon Chang, Tae Kong, Woo Kim, Seung-Chul Yoo, Jong-Hyuck Yoon, Ki-Hong Chang, Hee-Sug Ryu] Background: The purpose of this study was to investigate various pathologic risk factors associated with para-aortic lymph node metastasis (LNM) in surgically staged patients with endometrial cancer. Materials and Methods: We performed a retrospective analysis of 203 consecutive patients with endometrial cancer who were surgically staged from 2000 to 2009. The association among the various pathologic variables for para-aortic LNM was determined with univariate and multivariate analyses. Results: Of 203 patients, 29 patients (14.3%) had LNM. Also, 10 patients (4.9%) had only pelvic LNM, 14 (6.9%) had both pelvic and para-aortic LNM, and 5 (2.5%) had para-aortic LNM without pelvic LN involvements. Histologic type (P=.001), tumor grade (P<.001), tumor size (P=.003), depth of myometrial invasion (P<.001), cervical invasion (P<.001), parametrial invasion (P=.002), lymph-vascular space invasion (LVSI) (P<.001), serosal/adnexal invasion (P<.001), positive cytology (P=.002), peritoneal seeding (P<.001), and pelvic LNM (P<.001) were significant pathologic factors for para-aortic LNM. On multivariate analysis, cervical invasion (P=.032), LVSI (P=.018), and positive pelvic LNs (P=.002) were independent factors for para-aortic LNM. With regard to isolated para-aortic LNM, tumor grade (P=.017) and LVSI (P=.002) were significant factors for LN involvements. On multivariate analysis, LVSI (P=.004) was the only significant independent factor. Conclusions: LVSI correlates significantly with the risk of isolated para-aortic LNM in endometrial cancer patients. Society of Surgical Oncology, 2010 Chang Suk-Joon Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut Kong Tae Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut Kim Woo Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut Yoo Seung-Chul Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut Yoon Jong-Hyuck Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut Chang Ki-Hong Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut Ryu Hee-Sug Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 58-64 1068-9265 18:1<58 2011 18 10434 https://doi.org/10.1245/s10434-010-1206-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1206-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chang Suk-Joon Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut NATIONALLICENCE 700 1- Kong Tae Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut NATIONALLICENCE 700 1- Kim Woo Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut NATIONALLICENCE 700 1- Yoo Seung-Chul Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut NATIONALLICENCE 700 1- Yoon Jong-Hyuck Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut NATIONALLICENCE 700 1- Chang Ki-Hong Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut NATIONALLICENCE 700 1- Ryu Hee-Sug Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 58-64 1068-9265 18:1<58 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer