caa a22 4500 445332751 CHVBK 20180317142742.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1242-6 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1242-6 Supratentorial Glioblastoma Multiforme: The Role of Surgical Resection Versus Biopsy Among Older Patients [Elektronische Daten] [Kaisorn Chaichana, Tomas Garzon-Muvdi, Scott Parker, Jon Weingart, Alessandro Olivi, Richard Bennett, Henry Brem, Alfredo Quiñones-Hinojosa] Background: The peak incidence of glioblastoma multiforme (GBM) occurs in those aged 65years and older. However, studies on this patient group remain limited. The goal of this study is to evaluate the efficacy of surgery versus biopsy for older patients with these lesions. Methods: 133 and 72 consecutive patients aged 65years and older who underwent surgery and needle biopsy for intracranial primary (de novo) GBM between 1997 and 2007 were retrospectively reviewed. Among these patients, 40 who underwent surgical resection were matched with 40 who underwent needle biopsy alone for factors consistently shown to be associated with survival [age, Karnofsky Performance Scale (KPS) indexing, eloquent involvement, radiation, temozolomide]. Survival was expressed as estimated Kaplan-Meier plots, and log-rank analysis was used to compare survival curves. Results: Mean±standard deviation age was 73±5years, and mediansurvival was 4.9months. There were no significant differences in perioperative outcomes among patients who underwent surgical resection versus needle biopsy. Patients who underwent resection had median survival of 5.7months as compared with 4.0months for patients who underwent needle biopsy (P=0.02). Likewise, for patients aged 70years and older, median survival was 4.5months for 26 patients who underwent surgical resection as compared with 3.0months for 26 patients who underwent needle biopsy (P=0.03). Conclusion: This study demonstrates that older patients tolerate aggressive surgery without increased surgery-related morbidity and have prolonged survival as compared with similar patients undergoing needle biopsy. These findings may help guide treatment decisions for patients, their families, and their physicians. Society of Surgical Oncology, 2010 Chaichana Kaisorn The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Garzon-Muvdi Tomas The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Parker Scott The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Weingart Jon The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Olivi Alessandro The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Bennett Richard The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Brem Henry The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Quiñones-Hinojosa Alfredo The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 239-245 1068-9265 18:1<239 2011 18 10434 https://doi.org/10.1245/s10434-010-1242-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1242-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chaichana Kaisorn The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Garzon-Muvdi Tomas The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Parker Scott The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Weingart Jon The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Olivi Alessandro The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Bennett Richard The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Brem Henry The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Quiñones-Hinojosa Alfredo The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Departments of Neurosurgery, Oncology and Medicine, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 239-245 1068-9265 18:1<239 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer