caa a22 4500 445332794 CHVBK 20180317142742.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1214-x doi (NATIONALLICENCE)springer-10.1245/s10434-010-1214-x Predictors of Local Recurrence in a Population-Based Cohort of Women with Ductal Carcinoma In Situ Treated with Breast Conserving Surgery Alone [Elektronische Daten] [Elaine Wai, Mary Lesperance, Cheryl Alexander, Pauline Truong, Patrizia Moccia, Matthew Culp, Jennifer Lindquist, Ivo Olivotto] Background: To identify prognostic indicators of local recurrence (LR) in patients with ductal carcinoma in situ (DCIS) of the breast treated with breast conserving surgery (BCS) alone. Methods: A retrospective study was conducted of all women with pure DCIS, diagnosed 1985-1999, referred for tertiary oncologic opinion in British Columbia, treated with BCS without adjuvant radiotherapy. Kaplan-Meier local control (LC) and breast cancer specific survival (BCSS) estimates for the entire group were plotted. Stratified analyses identified subgroups with high Kaplan-Meier 10-year LR. Cox multivariate modeling was used to assess predictors of LR. Kaplan-Meier BCSS rates were compared between two cohorts: those who experienced LR and those who did not have LR. Results: A total of 460 women comprised the study cohort. Median follow-up was 9.4years. The 15-year LC and BCSS rates were 82% and 97%, respectively. Stratified analyses of LR identified comedo histology, high nuclear grade, tumor size >4cm or indeterminate size, and positive margins to be associated with significantly higher LR risk, with 10-year LR risks approximating 15-30%. The 10-year BCSS rates for the LR group were 94% compared with 99% for the NoLR group. On Cox regression modeling, high nuclear grade, the presence of comedocarcinoma, and positive margins were significant factors for higher risk of LR. Conclusions: Women with DCIS treated with BCS alone had higher LR risk, and those with a LR were more likely to die of breast cancer. Optimal local treatment is mandatory to minimize the risk of breast cancer death for women with this curable disease. Society of Surgical Oncology, 2010 Wai Elaine Radiation Therapy Program, BC Cancer Agency—Vancouver Island Centre, Victoria, BC, Canada aut Lesperance Mary Department of Mathematics and Statistics, University of Victoria, Victoria, BC, Canada aut Alexander Cheryl Breast Cancer Outcomes Unit, BC Cancer Agency, Victoria, BC, Canada aut Truong Pauline Radiation Therapy Program, BC Cancer Agency—Vancouver Island Centre, Victoria, BC, Canada aut Moccia Patrizia Department of Dermatology, University of British Columbia, Vancouver, BC, Canada aut Culp Matthew Memorial University of Newfoundland, St. John's, NL, Canada aut Lindquist Jennifer Department of Mathematics and Statistics, University of Victoria, Victoria, BC, Canada aut Olivotto Ivo Radiation Therapy Program, BC Cancer Agency—Vancouver Island Centre, Victoria, BC, Canada aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 119-124 1068-9265 18:1<119 2011 18 10434 https://doi.org/10.1245/s10434-010-1214-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1214-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wai Elaine Radiation Therapy Program, BC Cancer Agency—Vancouver Island Centre, Victoria, BC, Canada aut NATIONALLICENCE 700 1- Lesperance Mary Department of Mathematics and Statistics, University of Victoria, Victoria, BC, Canada aut NATIONALLICENCE 700 1- Alexander Cheryl Breast Cancer Outcomes Unit, BC Cancer Agency, Victoria, BC, Canada aut NATIONALLICENCE 700 1- Truong Pauline Radiation Therapy Program, BC Cancer Agency—Vancouver Island Centre, Victoria, BC, Canada aut NATIONALLICENCE 700 1- Moccia Patrizia Department of Dermatology, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Culp Matthew Memorial University of Newfoundland, St. John's, NL, Canada aut NATIONALLICENCE 700 1- Lindquist Jennifer Department of Mathematics and Statistics, University of Victoria, Victoria, BC, Canada aut NATIONALLICENCE 700 1- Olivotto Ivo Radiation Therapy Program, BC Cancer Agency—Vancouver Island Centre, Victoria, BC, Canada aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 119-124 1068-9265 18:1<119 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer