caa a22 4500 445332816 CHVBK 20180317142743.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1210-1 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1210-1 Severe Electrolyte Disturbances After Hyperthermic Intraperitoneal Chemotherapy: Oxaliplatin Versus Mitomycin C [Elektronische Daten] [Natasha Rueth, Sara Murray, Stephen Huddleston, Andrea Abbott, Edward Greeno, Mark Kirstein, Todd Tuttle] Background: Oxaliplatin (OX) is increasingly used for hyperthermic intraperitoneal chemotherapy (HIPC) for patients with peritoneal metastases. Our aim was to review electrolyte disturbances and complications after HIPC with oxaliplatin (OX) versus mitomycin C (MMC). Materials and Methods: We included patients enrolled in single-institution prospective clinical trials who underwent cytoreductive surgery and HIPC with MMC or OX. We reviewed patient demographics, pathology, perioperative course, HIPC administration, and postoperative electrolyte disturbances. Measured postoperative sodium values were corrected for systemic hyperglycemia using the formula: (measured Na+)×[(glucose−100/100)×1.6]. Results: From January 2002 to April 2009 we performed 80 HIPC procedures. A total of 60 patients (75%) received MMC (dose range 12.5-50mg/m2) carried in lactated ringers solution. There were 20 patients (25%) who received OX (dose range 300×400mg/m2) carried in 5% dextrose solution. For patients receiving HIPC with OX, electrolyte disturbances were the most common complication. Compared with MMC, patients receiving OX had significant 24-h postoperative uncorrected hyponatremia (P<0.001), corrected hyponatremia (P<0.001), hyperglycemia (P<0.001), and metabolic acidosis (P<0.001). In the OX group, corrected (mean 130.5) and uncorrected (mean 127.4) sodium levels were significantly lower than preoperatively (mean 139.9, P<0.001). The overall nonelectrolyte complication rate was 56.2%. (MMC n=33, 55.0%; OX n=12, 60%); the 30-day mortality rate was 0% in both groups. Conclusions: Compared with MMC, HIPC with OX was associated with significant but predictable electrolyte disturbances; however, these electrolyte disturbances were not associated with higher overall complication rates. Close monitoring with early correction is imperative to maximize perioperative care. Further studies are needed to provide mechanistic insight. Society of Surgical Oncology, 2010 Rueth Natasha Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut Murray Sara Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut Huddleston Stephen Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut Abbott Andrea Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut Greeno Edward Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA aut Kirstein Mark Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN, USA aut Tuttle Todd Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 174-180 1068-9265 18:1<174 2011 18 10434 https://doi.org/10.1245/s10434-010-1210-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1210-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rueth Natasha Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Murray Sara Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Huddleston Stephen Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Abbott Andrea Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Greeno Edward Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Kirstein Mark Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Tuttle Todd Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 174-180 1068-9265 18:1<174 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer