caa a22 4500 445332840 CHVBK 20180317142743.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1221-y doi (NATIONALLICENCE)springer-10.1245/s10434-010-1221-y Simultaneous Indocyanine Green and 99mTc-Antimony Sulfur Colloid-Guided Laparoscopic Sentinel Basin Dissection for Gastric Cancer [Elektronische Daten] [Do Park, Hyung-Ho Kim, Young Park, Hye Lee, Won Lee, Hyuk-Joon Lee, Han-Kwang Yang] Background: There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and 99mTc-antimony sulfur colloid (ASC) injections. Methods: Sixty-eight patients were enrolled who had been diagnosed with cT1-T2 and cN0 stage gastric cancers. They underwent laparoscopic sentinel basin dissection between June 2005 and May 2008. ICG and 99mTc-tin colloid (separate injections in the first phase, n=16) or ICG and 99mTc-ASC (simultaneous injections in the second phase, n=52) were injected into the submucosa endoscopically. After performing the sentinel basin dissection, laparoscopy-assisted gastrectomy with curative lymphadenectomy was done. Green-stained or radioactive sentinel nodes (SNs) were analyzed by hematoxylin and eosin staining and by immunohistochemistry for cytokeratin. Results: SNs were identified in 62 of the 68 patients (91.2%; mean 3.3 per patient). Eighteen patients had lymph node metastases. The sensitivity and specificity were, respectively, 72.2 and 100% using the dye method and 83.3 and 100% by the isotope method. However, the dual dye/isotope procedure improved both sensitivity and specificity to 100%. Patients receiving this protocol had significantly more SNs than those receiving separate ICG and 99mTc-tin colloid injections (3.3 vs. 1.9, P=0.008). Conclusion: Simultaneous ICG and 99mTc-ASC-guided laparoscopic sentinel basin dissection is an effective tool for gastric cancer SN mapping, giving a high detection rate and excellent sensitivity. Society of Surgical Oncology, 2010 Park Do Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut Kim Hyung-Ho Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut Park Young Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut Lee Hye Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea aut Lee Won Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut Lee Hyuk-Joon Department of Surgery, Seoul National University Hospital, Seoul, Korea aut Yang Han-Kwang Department of Surgery, Seoul National University Hospital, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 160-165 1068-9265 18:1<160 2011 18 10434 https://doi.org/10.1245/s10434-010-1221-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1221-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Do Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut NATIONALLICENCE 700 1- Kim Hyung-Ho Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut NATIONALLICENCE 700 1- Park Young Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut NATIONALLICENCE 700 1- Lee Hye Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea aut NATIONALLICENCE 700 1- Lee Won Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut NATIONALLICENCE 700 1- Lee Hyuk-Joon Department of Surgery, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Yang Han-Kwang Department of Surgery, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 160-165 1068-9265 18:1<160 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer