caa a22 4500 445332875 CHVBK 20180317142743.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1198-6 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1198-6 Metaplastic Breast Cancer: To Radiate or Not to Radiate? [Elektronische Daten] [Warren Tseng, Steve Martinez] Background: The role of radiation therapy (RT) is unclear for metaplastic breast cancer (MBC). We hypothesized that RT would improve overall survival (OS) and disease-specific survival (DSS). Materials and Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database to identify MBC patients diagnosed from1988 to 2006. Univariate analyses of patient, tumor, and treatment-specific factors on OS and DSS were performed using the Kaplan-Meier method and differences among survival curves assessed via log rank. Variables assessed included patient age, race/ethnicity, histologic subtype, tumor grade, T stage, N stage, M stage, hormone receptor status, surgery type, and use of RT. Cox proportional hazards models used all univariate covariates. Risks of mortality were reported as hazard ratios (HR) with 95% confidence intervals (95% CI); significance was set at P≤0.05. Results: Among 1501 patients, RT was given to 580 (38.6%). Ten-year OS and DSS were 53.2, and 68.3%, respectively. In the overall analysis, RT provided an OS (HR 0.64; 95% CI, 0.51-0.82; P<0.001) and DSS (HR 0.74; CI, 0.56-0.96; P<0.03) benefit. When patients were stratified according to type of surgery, RT provided an OS but not a DSS benefit to lumpectomy (HR 0.51; CI, 0.32-0.79, P<0.01) and mastectomy patients (HR 0.67; CI, 0.49-0.90; P<0.01). Conclusions: Our findings support the use of RT for patients with MBC following lumpectomy or mastectomy. These retrospective findings should be confirmed in a prospective clinical trial. The Author(s), 2010 Tseng Warren Division of Surgical Oncology, Department of Surgery, University of California Davis, Sacramento, CA, USA aut Martinez Steve Division of Surgical Oncology, Department of Surgery, University of California Davis, Sacramento, CA, USA aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 94-103 1068-9265 18:1<94 2011 18 10434 https://doi.org/10.1245/s10434-010-1198-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1198-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tseng Warren Division of Surgical Oncology, Department of Surgery, University of California Davis, Sacramento, CA, USA aut NATIONALLICENCE 700 1- Martinez Steve Division of Surgical Oncology, Department of Surgery, University of California Davis, Sacramento, CA, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 94-103 1068-9265 18:1<94 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer