caa a22 4500 445332905 CHVBK 20180317142743.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1293-8 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1293-8 Prognostic Factors of a Large Retrospective Series of Mucinous Borderline Tumors of the Ovary (Excluding Peritoneal Pseudomyxoma) [Elektronische Daten] [Martin Koskas, Catherine Uzan, Sebastien Gouy, Patricia Pautier, Catherine Lhommé, Christine Haie-Meder, Pierre Duvillard, Philippe Morice] Background: To determine the prognosis and prognostic factors in a large series of mucinous borderline tumors of the ovary (MBOT). Materials and Methods: A retrospective review of patients with MBOT treated or referred to our institution. Three inclusion criteria were defined: (1) centralized histological review by our expert pathologist, (2) exclusion of peritoneal pseudomyxoma and any synchronous malignant tumor in the abdominal cavity, and (3) available data on the management and outcomes of patients. Results: From 1997 to 2004, 97 patients fulfilled inclusion criteria (95 stage I and 2 stage II disease). Of these, 9 patients had endocervical-like subtypes, 8 patients had stromal microinvasion, and 24 had intraepithelial carcinoma. Radical and conservative surgeries were performed, respectively, in 28 and 69 patients. After a median follow-up of 48months, 13 patients had developed 14 recurrences: 7 were borderline and 7 were invasive lesions. The probability of recurrence in the form of carcinoma 5 and 10years after the diagnosis was, respectively, 9 and 13%. The only prognostic factor for recurrence attaining statistical significance was the use of a cystectomy (compared with other surgeries relative risk [RR]=5.6; P=0.003; compared with salpingo-oophorectomy RR=5.5; P=0.012). Conclusions: In the present series of 97 MBOT, mainly early-stage disease and excluding peritoneal pseudomyxoma, the cumulative risk of recurrence in the form of invasive carcinoma at 10years was 13%. MBOT do not appear to be such a "safe” disease. The only prognostic factor for recurrence was the use of a cystectomy, suggesting that a salpingo-oophorectomy should be preferred in cases of conservative treatment. Society of Surgical Oncology, 2010 Koskas Martin Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France aut Uzan Catherine Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France aut Gouy Sebastien Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France aut Pautier Patricia Department of Oncology, Institut Gustave Roussy, Villejuif, France aut Lhommé Catherine Department of Oncology, Institut Gustave Roussy, Villejuif, France aut Haie-Meder Christine Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France aut Duvillard Pierre Department of Pathology, Institut Gustave Roussy, Villejuif, France aut Morice Philippe Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 40-48 1068-9265 18:1<40 2011 18 10434 https://doi.org/10.1245/s10434-010-1293-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1293-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koskas Martin Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Uzan Catherine Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Gouy Sebastien Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Pautier Patricia Department of Oncology, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Lhommé Catherine Department of Oncology, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Haie-Meder Christine Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Duvillard Pierre Department of Pathology, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Morice Philippe Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 40-48 1068-9265 18:1<40 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer