caa a22 4500 44533309X CHVBK 20180317142743.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1245/s10434-010-1228-4 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1228-4 Phase II Comparison Study of Intraoperative Autotransfusion for Major Oncologic Procedures [Elektronische Daten] [Matthew Bower, Susan Ellis, Charles Scoggins, Kelly McMasters, Robert Martin] Background: Intraoperative autotransfusion (IOAT) has been avoided in oncologic surgery because of possible tumor cell dissemination. Through a prior Phase I study, we demonstrated that malignant cells are not present in blood filtered for IOAT. We hypothesized that autotransfusion could be safely used for patients undergoing major oncologic procedures and reduce the need for allogeneic blood. Materials and Methods: A Phase II, IRB-approved, prospective evaluation was conducted of patients undergoing gastrointestinal oncologic procedures. All procedures were conducted with blood salvaged for IOAT, and the collected volume was autotransfused if it was >100ml. Quality of life (QoL) was assessed by questionnaire at regular intervals. Results: A total of 92 patients were enrolled with median age of 56years. The most commonly performed procedures were hepatectomy (47%) and pancreaticoduodenectomy (26%). The median preoperative hemoglobin (Hgb) was 13.1 (range, 9-16), and the median estimated blood loss was 350ml (range, 20-4000ml). Of the 92 total patients, 32 (35%) received IOAT with a median volume of 255ml (range, 117-1499ml). Multivariate analysis identified that patients with preoperative Hgb >11g/dl (P=.02), and blood loss of 400-900ml (P=.03) benefited from IOAT with a reduction in postoperative blood transfusion rate. Patients with discharge Hgb >10g/dl showed higher mean QoL scores throughout their recovery. At a median follow-up of 18months, the rates of recurrence in the IOAT and the non-IOAT groups were equivalent (38 vs. 39%, P=.9). Conclusions: Intraoperative autotransfusion can be used safely and effectively for major oncologic procedures. Furthermore, degree of discharge anemia is associated with lower quality of life in patients undergoing oncologic gastrointestinal surgery. Society of Surgical Oncology, 2010 Bower Matthew Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut Ellis Susan Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut Scoggins Charles Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut McMasters Kelly Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut Martin Robert Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 166-173 1068-9265 18:1<166 2011 18 10434 https://doi.org/10.1245/s10434-010-1228-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1228-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bower Matthew Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut NATIONALLICENCE 700 1- Ellis Susan Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut NATIONALLICENCE 700 1- Scoggins Charles Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut NATIONALLICENCE 700 1- McMasters Kelly Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut NATIONALLICENCE 700 1- Martin Robert Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/1(2011-01-01), 166-173 1068-9265 18:1<166 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer