caa a22 4500 445333146 CHVBK 20180317142744.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-010-1536-8 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1536-8 Tumor Volume Increase During Preoperative Chemotherapy as a Novel Predictor of Local Recurrence in Extremity Osteosarcoma [Elektronische Daten] [Won Song, Dae-Geun Jeon, Chang-Bae Kong, Wan Cho, Jae-Soo Koh, Jun Lee, Ji Yoo, Sung Jung, Duk Shin, Soo-Yong Lee] Background: Known risk factors (surgical margin, tumor necrosis) of local recurrence (LR) in osteosarcoma are determined by results available after surgery. However, relations between preoperative characteristics and LR have not been clearly defined. Methods: We compared the clinicopathologic characteristics of 36 osteosarcoma patients with LR and 394 patients without LR after surgery. In addition, prognostic variables were evaluated to establish factors could influence LR. Results: Compared to the non-LR group, the LR group showed an increase in tumor volume ratio (TVR) during preoperative chemotherapy (P<0.01), inadequate surgical margin (P<0.01), and poor histologic response (P<0.01). Univariate analysis of data from 430 patients revealed that an increased TVR (P<0.01), inadequate surgical margin (P<0.01), poor histologic response (P<0.01), and nonosteoblastic pathologic subtype (P=0.04) were negatively related to LR-free survival. In multivariate analysis, an elevated TVR (P<0.01, relative risk=10.26) and inadequate surgical margin (P<0.01, relative risk=5.91) emerged as the key prognostic factors for LR. Conclusions: A TVR increase during preoperative chemotherapy could be used to predict patients at high risk of LR. This finding might be useful when considering surgical options to decrease the risk of LR. Society of Surgical Oncology, 2011 Song Won Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut Jeon Dae-Geun Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut Kong Chang-Bae Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut Cho Wan Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut Koh Jae-Soo Department Pathology, Korea Cancer Center Hospital, Seoul, Korea aut Lee Jun Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea aut Yoo Ji Department of Radiology, Korea Cancer Center Hospital, Seoul, Korea aut Jung Sung Department of Orthopedic Surgery, Chonnam National University Medical School, Gwangju, Korea aut Shin Duk Department of Orthopedic Surgery, Yeungnam University College of Medicine, Daegu, Korea aut Lee Soo-Yong Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1710-1716 1068-9265 18:6<1710 2011 18 10434 https://doi.org/10.1245/s10434-010-1536-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1536-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Song Won Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Jeon Dae-Geun Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Kong Chang-Bae Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Cho Wan Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Koh Jae-Soo Department Pathology, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jun Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Yoo Ji Department of Radiology, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Jung Sung Department of Orthopedic Surgery, Chonnam National University Medical School, Gwangju, Korea aut NATIONALLICENCE 700 1- Shin Duk Department of Orthopedic Surgery, Yeungnam University College of Medicine, Daegu, Korea aut NATIONALLICENCE 700 1- Lee Soo-Yong Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1710-1716 1068-9265 18:6<1710 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer