caa a22 4500 445333251 CHVBK 20180317142744.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-010-1480-7 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1480-7 Multifocality in "Basal-Like” Breast Carcinomas and its Influence on Lymph Node Status [Elektronische Daten] [Tibor Tot, Gyula Pekár] Background: Basal-like breast carcinomas often are regarded for circumscribed solitary lesions having unfavorable prognosis. On the other hand, a considerable proportion of breast carcinomas is multifocal and has increased metastatic potential. In this study, we analyzed the subgross distribution of the lesions in a series of basal-like carcinomas, compared it with that in nonbasal-like tumors and studied the frequency of vascular invasion and lymph node metastasis in relation to focality of the lesions. Methods: A total of 511 consecutive cases documented in large-format histologic sections were studied. Tumors expressing at least one of the basal (myoepithelial) markers (CK5/6, CK14, EGFR) in at least one of the invasive tumor foci were categorized as basal-like tumors. Triple-negative (ER/PR/HER-2-negative) basal-like carcinomas also were analyzed. The distribution of lesions and the frequency of vascular invasion and lymph node metastasis were analyzed. The study was approved by the Regional Ethical Committee Uppsala-Örebro. Results: In 44% of cases, the invasive component was multifocal or diffuse. Combining the in situ and invasive tumor components resulted in 61% of cases with multifocal/diffuse distribution. The only statistically significant difference observed was that basal-like tumors lacked in situ components more often (21% vs. 9%; P=0.0075). No significant differences could be demonstrated regarding vascular invasion and lymph node status. Lymph node metastasis appeared significantly more frequently in multifocal cases in both tumor categories. Conclusions: Basal-like breast carcinomas are as frequently multifocal as their non-basal-like counterparts; multifocality is associated with increased risk for vascular invasion and lymph node metastasis in both tumor categories. Society of Surgical Oncology, 2010 Tot Tibor Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden aut Pekár Gyula Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1671-1677 1068-9265 18:6<1671 2011 18 10434 https://doi.org/10.1245/s10434-010-1480-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1480-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tot Tibor Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden aut NATIONALLICENCE 700 1- Pekár Gyula Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1671-1677 1068-9265 18:6<1671 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer