caa a22 4500 445333308 CHVBK 20180317142744.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-010-1508-z doi (NATIONALLICENCE)springer-10.1245/s10434-010-1508-z Defining Cure for Esophageal Cancer: Analysis of Actual 5-Year Survivors Following Esophagectomy [Elektronische Daten] [Jodi Hirst, Bernard Smithers, David Gotley, Janine Thomas, Andrew Barbour] Background: Esophagectomy is the mainstay of curative treatment for localized esophageal cancer. However, what constitutes cure is not well defined. This study was undertaken to characterize actual 5-year survivors following esophagectomy and to determine prognostic factors for disease-specific survival (DSS) from 60months. Materials and Methods: Between 1987 and 2004, 398 consecutive patients underwent esophagectomy and had potential for 5years follow-up. Clinicopathological factors associated with DSS from 5years onward were analyzed. Results: Median DSS was 25months. Neoadjuvant therapy was administered to 159 of 398 (40%). There were 114 of 398 (29%) actual 5-year survivors. On multivariate analysis, 5-year survivors were significantly more likely to have lower T classification, N classification, and R0 resections compared with patients who died less than 5years after surgery. There were 66 of 398 patients (17%) with positive margins, and 6 of these were 5-year survivors. Of the 114 5-year survivors, 17 (15%) subsequently died of esophageal cancer. Prognostic factors for DSS after surviving 5years were age and T classification for patients treated with neoadjuvant therapy and surgery alone, respectively. Powerful prognostic factors from time of treatment, including nodal status, were no longer prognostic factors after surviving to 5years. Conclusions: No single clinicopathological variable negated survival to 5years. Prognostication once surviving 5years is difficult. The majority of 5-year survivors can be considered cured of esophageal cancer. Society of Surgical Oncology, 2011 Hirst Jodi Department of Surgery, The University of Queensland, St Lucia, Australia aut Smithers Bernard Department of Surgery, The University of Queensland, St Lucia, Australia aut Gotley David Department of Surgery, The University of Queensland, St Lucia, Australia aut Thomas Janine Department of Surgery, Princess Alexandra Hospital, Brisbane, Australia aut Barbour Andrew Department of Surgery, The University of Queensland, St Lucia, Australia aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1766-1774 1068-9265 18:6<1766 2011 18 10434 https://doi.org/10.1245/s10434-010-1508-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1508-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hirst Jodi Department of Surgery, The University of Queensland, St Lucia, Australia aut NATIONALLICENCE 700 1- Smithers Bernard Department of Surgery, The University of Queensland, St Lucia, Australia aut NATIONALLICENCE 700 1- Gotley David Department of Surgery, The University of Queensland, St Lucia, Australia aut NATIONALLICENCE 700 1- Thomas Janine Department of Surgery, Princess Alexandra Hospital, Brisbane, Australia aut NATIONALLICENCE 700 1- Barbour Andrew Department of Surgery, The University of Queensland, St Lucia, Australia aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1766-1774 1068-9265 18:6<1766 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer