caa a22 4500 445333332 CHVBK 20180317142744.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-011-1671-x doi (NATIONALLICENCE)springer-10.1245/s10434-011-1671-x Importance of the First Postoperative Year in the Prognosis of Elderly Colorectal Cancer Patients [Elektronische Daten] [J. Dekker, C. van den Broek, E. Bastiaannet, L. van de Geest, R. Tollenaar, G. Liefers] Background: Elderly colorectal cancer patients have worse prognosis than younger patients. Age-related survival differences may be cancer or treatment related, but also due to death from other causes. This study aims to compare population-based survival data for young (<65years), aged (65-74years), and elderly (≥75years) colorectal cancer patients. Methods: All patients operated for stage I-III colorectal cancer between 1991 and 2005 in the western region of The Netherlands were included. Crude survival, relative survival, and conditional relative survival curves, under the condition of surviving 1year, were made for colon and rectal cancer patients separately. Furthermore, 30-day, 1-year, and 1-year excess mortality data were compared. Results: A total of 9,397 stage I-III colorectal cancer patients were included in this study. Crude survival curves showed clear survival differences between the age groups. These age-related differences were less prominent in relative survival and disappeared in conditional relative survival (CRS). Only in stage III disease did elderly patients have worse CRS than young patients. Furthermore, significant age-related differences in 30-day and 1-year excess mortality were found. Thirty-day mortality vastly underestimated 1-year mortality for all age groups. Conclusions: Elderly colorectal cancer patients who survive the first year have the same cancer-related survival as younger patients. Therefore, decreased survival in the elderly is mainly due to differences in early mortality. Treatment of elderly colorectal cancer patients should focus on perioperative care and the first postoperative year. The Author(s), 2011 Dekker J. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut van den Broek C. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut Bastiaannet E. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut van de Geest L. Comprehensive Cancer Centre West, Leiden, The Netherlands aut Tollenaar R. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut Liefers G. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1533-1539 1068-9265 18:6<1533 2011 18 10434 https://doi.org/10.1245/s10434-011-1671-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1671-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dekker J. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut NATIONALLICENCE 700 1- van den Broek C. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Bastiaannet E. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut NATIONALLICENCE 700 1- van de Geest L. Comprehensive Cancer Centre West, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Tollenaar R. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Liefers G. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1533-1539 1068-9265 18:6<1533 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer