caa a22 4500 445333340 CHVBK 20180317142744.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-010-1532-z doi (NATIONALLICENCE)springer-10.1245/s10434-010-1532-z A Systematic Review and Meta-analysis of Intralesional Versus Wide Resection for Intramedullary Grade I Chondrosarcoma of the Extremities [Elektronische Daten] [Michael Hickey, Forough Farrokhyar, Ben Deheshi, Robert Turcotte, Michelle Ghert] Background: The surgical management of grade I intramedullary chondrosarcoma of bone remains controversial. The purpose of this study was to perform a systematic review and meta-analysis of published data to determine the oncologic outcomes of intralesional versus wide resection for grade I intramedullary chondrosarcoma. Methods: Literature searches were performed through Medline, EMBASE, and the Cochrane Database. Cohort studies in which one patient group with grade I chondrosarcoma underwent wide resection and one underwent intralesional curettage were included. Two reviewers independently assessed all eligible papers with the Newcastle-Ottawa Quality Assessment Scale for Cohort Studies. The outcome measures were the pooled odds ratio and 95% confidence intervals for the risk of local recurrence and metastasis calculated through the random-effects method. Results: Five eligible studies were identified including a total of 190 patients, 78 of whom underwent intralesional resection and 112 of whom underwent wide resection. Only one pelvic lesion was identified, which underwent wide resection. There were a total of five local recurrences and three metastases. The risk for local recurrence and metastasis did not differ significantly between the two groups, with an odds ratio for intralesional resection of 2.26 (95% confidence interval, 0.41-12.62) and 0.44 (95% confidence interval, 0.04-5.21) respectively. Conclusions: Intralesional curettage as an alternative to wide resection for extrapelvic grade I chondrosarcoma of bone does not greatly increase the risk for local recurrence or metastasis. Overall effect estimates, however, should be interpreted with caution as a result of the relatively small number of events. Society of Surgical Oncology, 2011 Hickey Michael Department of Surgery, McMaster University, Hamilton, ON, Canada aut Farrokhyar Forough Department of Surgery, McMaster University, Hamilton, ON, Canada aut Deheshi Ben Department of Surgery, McMaster University, Hamilton, ON, Canada aut Turcotte Robert Department of Orthopaedic Surgery, McGill University Health Centre, Montreal, QC, Canada aut Ghert Michelle Department of Surgery, McMaster University, Hamilton, ON, Canada aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1705-1709 1068-9265 18:6<1705 2011 18 10434 https://doi.org/10.1245/s10434-010-1532-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1532-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hickey Michael Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Farrokhyar Forough Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Deheshi Ben Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Turcotte Robert Department of Orthopaedic Surgery, McGill University Health Centre, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Ghert Michelle Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1705-1709 1068-9265 18:6<1705 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer