caa a22 4500 44533343X CHVBK 20180317142745.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-010-1529-7 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1529-7 Preoperative Serum CA 19-9 Level as a Predictive Factor for Recurrence after Curative Resection in Biliary Tract Cancer [Elektronische Daten] [Moon Chung, Kyong Lee, Seungmin Bang, Seung Park, Kyung Kim, Woo Lee, Si Song, Jae Chung, Jeong Park] Background: Complete surgical removal of biliary tract cancer (BTC) offers the only chance of cure; however, long-term survival remains very limited because of frequent recurrence after surgery. The purpose of our study was to evaluate whether the preoperative serum carbohydrate antigen (CA) 19-9 level could predict recurrence after curative resection of BTC. Methods: We performed a retrospective review of the medical records of patients who were diagnosed with BTC and underwent curative resection. The optimal cutoff value for the preoperative serum level of CA 19-9 that predicted recurrence was determined by a ROC curve. Preoperative and postoperative risk factors for recurrence were evaluated using log-rank test. Results: A total of 101 patients were eligible for this study. The optimal cutoff value of preoperative serum CA 19-9 level to predict recurrence was 55U/mL. Forty-five patients (44.6%) experienced recurrence after curative resection with a median follow-up period of 28.4months. Recurrence occurred in 33 (61.1%) of 54 patients with CA 19-9 levels ≥55U/mL compared with only 12 (25.5%) of 47 patients with CA 19-9 levels <55U/mL. The recurrence rate was significantly higher in patients with baseline CA 19-9 serum levels ≥55U/mL (hazard ratio, 3.282; 95% confidence interval, 1.684-6.395; P<0.001). Conclusions: Elevated preoperative serum CA 19-9 was associated with a high risk of recurrence after curative resection of BTC. Different treatment plans might be needed for patients with BTC and high serum levels of CA 19-9. Society of Surgical Oncology, 2011 Chung Moon Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut Lee Kyong Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut Bang Seungmin Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut Park Seung Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut Kim Kyung Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Lee Woo Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Song Si Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut Chung Jae Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut Park Jeong Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1651-1656 1068-9265 18:6<1651 2011 18 10434 https://doi.org/10.1245/s10434-010-1529-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1529-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chung Moon Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Kyong Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Bang Seungmin Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Park Seung Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kyung Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Woo Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Song Si Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Chung Jae Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Park Jeong Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1651-1656 1068-9265 18:6<1651 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer