caa a22 4500 445333499 CHVBK 20180317142745.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-011-1714-3 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1714-3 Surgical Cytoreduction and Survival in Appendiceal Cancer Peritoneal Carcinomatosis: An Evaluation of 46 Consecutive Patients [Elektronische Daten] [Terence Chua, Ihssan Al-Alem, Akshat Saxena, Winston Liauw, David Morris] Background: Surgical cytoreduction and intraperitoneal chemotherapy is increasingly accepted as an effective treatment modality for mucinous appendiceal neoplasm. For the majority of patients with low-grade histology, outcomes have been encouraging. The survival of patients with neoplasms of malignant character is protracted and this study was designed to evaluate the effectiveness of this surgical strategy on outcomes. Methods: Forty-six consecutive patients with mucinous and nonmucinous appendiceal cancer with peritoneal dissemination were studied. Clinicopathological and treatment related factors were obtained from a prospective database. The study's end points of disease-free survival (DFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Results: The median DFS and OS after cytoreduction were 20.5 and 56.4months respectively. Five-year overall survival rate was 45%. Five independent factors associated with DFS and OS were identified through a multivariate analysis: age (DFS p=0.001, OS p=0.002), completeness of cytoreduction (DFS p=0.001, OS p=0.003), previous chemotherapy treatment (DFS p=0.021), CA 199 levels (DFS p=0.013), and tumor grade (OS p=0.005). Conclusions: Cytoreductive surgery and intraperitoneal chemotherapy may achieve long-term survival in appendiceal malignancies with peritoneal dissemination for which the predictors of outcomes identified through this study may tailor the disease management to commit patients early toward this successful surgical strategy. Society of Surgical Oncology, 2011 Chua Terence Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Australia aut Al-Alem Ihssan Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Australia aut Saxena Akshat Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Australia aut Liauw Winston Department of Medical Oncology, Cancer Care Centre, St George Hospital, Sydney, NSW, Australia aut Morris David Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Australia aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1540-1546 1068-9265 18:6<1540 2011 18 10434 https://doi.org/10.1245/s10434-011-1714-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1714-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chua Terence Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Al-Alem Ihssan Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Saxena Akshat Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Liauw Winston Department of Medical Oncology, Cancer Care Centre, St George Hospital, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Morris David Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1540-1546 1068-9265 18:6<1540 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer