caa a22 4500 445333502 CHVBK 20180317142745.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-010-1543-9 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1543-9 Do Perioperative Blood Transfusions Influence Prognosis of Gastric Cancer Patients? Analysis of 927 Patients and Interactions with Splenectomy [Elektronische Daten] [Fabio Pacelli, Fausto Rosa, Daniele Marrelli, Corrado Pedrazzani, Maurizio Bossola, Marco Zoccali, Alberto Marchet, Mariantonietta Cosmo, Claudia Roata, Luigina Graziosi, Emanuel Cavazzoni, Marcello Covino, Domenico D'Ugo, Franco Roviello, Donato Nitti, Giovanni Doglietto] Background: This study was to assess the influence of perioperative blood transfusions on the prognosis of patients undergoing a potentially curative resection for gastric cancer and to investigate the interaction between transfusions and splenectomy. Materials and Methods: Between January 1990 and December 2005, 927 patients from 6 Italian tertiary referral centers underwent curative resections for gastric cancer. Clinical and pathologic variables were prospectively collected. The influence of perioperative blood transfusions on survival were evaluated by univariate and multivariate analysis. Moreover, the influence of splenectomy both in transfused and nontransfused patients undergoing total gastrectomy was also evaluated. Results: The overall 5-year survival was 54.6%. The 5-year survival rate in transfused patients (n=327) was 50.6% compared with 56.6% in nontransfused patients (n=600) (P=.094). In the subgroup of patients who underwent total gastrectomy with spleen preservation (n=209), 5-year survival rate was 46% and 51.4% in transfused and nontransfused patients, respectively (P=.418); those who underwent total gastrectomy with splenectomy (n=199) presented a 5-year survival rate of 45% in transfused group compared with 39.1% in nontransfused patients (P=.571). Conclusions: Our study indicates a slightly, but not significantly, negative effect of allogeneic blood transfusion on prognosis of gastric cancer patients. In the subgroup of patients who underwent total gastrectomy, splenectomy seems to invert this mild effect, with a positive influence on overall survival. Society of Surgical Oncology, 2011 Pacelli Fabio Department of Digestive Surgery, Catholic University of Rome, Rome, Italy aut Rosa Fausto Department of Digestive Surgery, Catholic University of Rome, Rome, Italy aut Marrelli Daniele Institute of Surgical Sciences, University of Siena, Seina, Italy aut Pedrazzani Corrado Institute of Surgical Sciences, University of Siena, Seina, Italy aut Bossola Maurizio Department of Digestive Surgery, Catholic University of Rome, Rome, Italy aut Zoccali Marco 1st General Surgery, Catholic University of Rome, Rome, Italy aut Marchet Alberto Clinica Chirurgica Generale 2, University of Padova, Padova, Italy aut Cosmo Mariantonietta 1st Division of Surgery, University of Verona, Verona, Italy aut Roata Claudia Servizio Trasfusionale, Borgo Trento Hospital, Verona, Italy aut Graziosi Luigina Section of General and Emergency Surgery, University of Perugia, Perugia, Italy aut Cavazzoni Emanuel Section of General and Emergency Surgery, University of Perugia, Perugia, Italy aut Covino Marcello Department of Emergency Medicine, Catholic University of Rome, Rome, Italy aut D'Ugo Domenico 1st General Surgery, Catholic University of Rome, Rome, Italy aut Roviello Franco Institute of Surgical Sciences, University of Siena, Seina, Italy aut Nitti Donato Clinica Chirurgica Generale 2, University of Padova, Padova, Italy aut Doglietto Giovanni Department of Digestive Surgery, Catholic University of Rome, Rome, Italy aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1615-1623 1068-9265 18:6<1615 2011 18 10434 https://doi.org/10.1245/s10434-010-1543-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1543-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pacelli Fabio Department of Digestive Surgery, Catholic University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Rosa Fausto Department of Digestive Surgery, Catholic University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Marrelli Daniele Institute of Surgical Sciences, University of Siena, Seina, Italy aut NATIONALLICENCE 700 1- Pedrazzani Corrado Institute of Surgical Sciences, University of Siena, Seina, Italy aut NATIONALLICENCE 700 1- Bossola Maurizio Department of Digestive Surgery, Catholic University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Zoccali Marco 1st General Surgery, Catholic University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Marchet Alberto Clinica Chirurgica Generale 2, University of Padova, Padova, Italy aut NATIONALLICENCE 700 1- Cosmo Mariantonietta 1st Division of Surgery, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Roata Claudia Servizio Trasfusionale, Borgo Trento Hospital, Verona, Italy aut NATIONALLICENCE 700 1- Graziosi Luigina Section of General and Emergency Surgery, University of Perugia, Perugia, Italy aut NATIONALLICENCE 700 1- Cavazzoni Emanuel Section of General and Emergency Surgery, University of Perugia, Perugia, Italy aut NATIONALLICENCE 700 1- Covino Marcello Department of Emergency Medicine, Catholic University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- D'Ugo Domenico 1st General Surgery, Catholic University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Roviello Franco Institute of Surgical Sciences, University of Siena, Seina, Italy aut NATIONALLICENCE 700 1- Nitti Donato Clinica Chirurgica Generale 2, University of Padova, Padova, Italy aut NATIONALLICENCE 700 1- Doglietto Giovanni Department of Digestive Surgery, Catholic University of Rome, Rome, Italy aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1615-1623 1068-9265 18:6<1615 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer