caa a22 4500 445333510 CHVBK 20180317142745.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-011-1673-8 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1673-8 Medium-Sized (3.1-5.0cm) Hepatocellular Carcinoma: Transarterial Chemoembolization Plus Radiofrequency Ablation Versus Radiofrequency Ablation Alone [Elektronische Daten] [Jin Kim, Hyung Won, Yong Shin, Sung Kim, Hyun-Ki Yoon, Kyu-Bo Sung, Pyo Kim] Purpose: This study was designed to retrospectively compare the effectiveness of combined transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) with that of RFA alone in patients with medium-sized (3.1-5.0cm) hepatocellular carcinoma (HCC). Methods: From March 2000 to April 2010, 57 patients, each with a single medium-sized HCC, were treated with combined TACE and RFA, and 66 were treated with RFA alone. Results: During follow-up (mean, 42.5±33.2months; range, 2.6-126.2months), local tumor progression was observed in 40% of treated lesions in the combined treatment group and in 70% in the RFA-alone group. The 1-, 3-, 5-, and 7-year local tumor progression rates were significantly lower in the TACE+RFA group (9%, 40%, 55%, and 66%, respectively) than in the RFA-alone group (45%, 76%, 86%, and 89%, respectively; P<0.001). Multivariate analysis showed that treatment allocation (odds ratio [OR], 1.78; P=0.016) and Child-Pugh class (OR, 1.96; P=0.008) were significant independent factors associated with patient survival. The rates of major complications were 0% for the combined treatment group and 3% for the RFA-alone group. Conclusions: The combination of TACE and RFA is safe and provides better local tumor control than RFA alone for the treatment of patients with medium-sized HCC. Our multivariate analysis showed that RFA-alone treatment and Child-Pugh class B were poor independent factors for determining the patient survival period. Society of Surgical Oncology, 2011 Kim Jin Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Won Hyung Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Shin Yong Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Kim Sung Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Yoon Hyun-Ki Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Sung Kyu-Bo Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Kim Pyo Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1624-1629 1068-9265 18:6<1624 2011 18 10434 https://doi.org/10.1245/s10434-011-1673-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1673-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Jin Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Won Hyung Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Shin Yong Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Sung Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Yoon Hyun-Ki Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Sung Kyu-Bo Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Pyo Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1624-1629 1068-9265 18:6<1624 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer