caa a22 4500 445333529 CHVBK 20180317142745.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-010-1545-7 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1545-7 Validation of the S Classification of Sentinel Lymph Node and Microanatomic Location of Sentinel Lymph Node Metastases to Predict Additional Lymph Node Involvement and Overall Survival in Breast Cancer Patients [Elektronische Daten] [Astrid Fink, Hannes Wondratsch, Harald Lass, Michael Janauer, Paul Sevelda, Heinrich Salzer, Wolfgang Jurecka, Walter Ulrich, Andreas Chott, Andreas Steiner] Background: Most patients with a positive sentinel lymph node (SN) have no further metastases in the axillary lymph nodes and may therefore not benefit from axillary lymph node dissection. In patients with melanoma, evaluation of the centripetal depth of tumor invasion in the SN, also known as the S classification of SN, and microanatomic localization of SN metastases were shown to predict non-SN involvement. This phenomenon has been less extensively studied in breast cancer. We sought to validate the S classification and microanatomic location of SN metastases in breast cancer patients with regard to their predictive value for non-SN involvement and overall survival (OS). Methods: A total of 236 patients with positive SN followed by axillary lymph node dissection were reevaluated according to the S classification and the microanatomic location of SN (subcapsular, parenchymal, combined subcapsular and parenchymal, multifocal, extensive) metastases to predict the likelihood of non-SN metastases and OS. Results: S classification and the microanatomic location of SN metastases were significantly correlated with non-SN status (P<0.001). Especially patients with a maximum depth of invasion ≤0.3mm (stage I according to the S classification) and those with SN metastases only in subcapsular location had a low probability of further non-SN metastases (7.8 and 6.1%) and a good prognosis for OS. Conclusions: S classification and microanatomic location of SN metastases predicts the likelihood of non-SN involvement. Especially patients with subcapsular or S stage I metastases have a low probability of non-SN metastases and a good prognosis for OS. Society of Surgical Oncology, 2011 Fink Astrid Department of Dermatology, Wilhelminenspital, Vienna, Austria aut Wondratsch Hannes Department of Dermatology, Krankenhaus Hietzing, Vienna, Austria aut Lass Harald Department of Obstetrics and Gynecology, Wilhelminenspital, Vienna, Austria aut Janauer Michael Department of Obstetrics and Gynecology, Krankenhaus Hietzing, Vienna, Austria aut Sevelda Paul Department of Obstetrics and Gynecology, Krankenhaus Hietzing, Vienna, Austria aut Salzer Heinrich Department of Obstetrics and Gynecology, Wilhelminenspital, Vienna, Austria aut Jurecka Wolfgang Department of Dermatology, Wilhelminenspital, Vienna, Austria aut Ulrich Walter Department of Pathology, Krankenhaus Hietzing, Vienna, Austria aut Chott Andreas Department of Pathology, Wilhelminenspital, Vienna, Austria aut Steiner Andreas Department of Dermatology, Krankenhaus Hietzing, Vienna, Austria aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1691-1697 1068-9265 18:6<1691 2011 18 10434 https://doi.org/10.1245/s10434-010-1545-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1545-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fink Astrid Department of Dermatology, Wilhelminenspital, Vienna, Austria aut NATIONALLICENCE 700 1- Wondratsch Hannes Department of Dermatology, Krankenhaus Hietzing, Vienna, Austria aut NATIONALLICENCE 700 1- Lass Harald Department of Obstetrics and Gynecology, Wilhelminenspital, Vienna, Austria aut NATIONALLICENCE 700 1- Janauer Michael Department of Obstetrics and Gynecology, Krankenhaus Hietzing, Vienna, Austria aut NATIONALLICENCE 700 1- Sevelda Paul Department of Obstetrics and Gynecology, Krankenhaus Hietzing, Vienna, Austria aut NATIONALLICENCE 700 1- Salzer Heinrich Department of Obstetrics and Gynecology, Wilhelminenspital, Vienna, Austria aut NATIONALLICENCE 700 1- Jurecka Wolfgang Department of Dermatology, Wilhelminenspital, Vienna, Austria aut NATIONALLICENCE 700 1- Ulrich Walter Department of Pathology, Krankenhaus Hietzing, Vienna, Austria aut NATIONALLICENCE 700 1- Chott Andreas Department of Pathology, Wilhelminenspital, Vienna, Austria aut NATIONALLICENCE 700 1- Steiner Andreas Department of Dermatology, Krankenhaus Hietzing, Vienna, Austria aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1691-1697 1068-9265 18:6<1691 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer