caa a22 4500 44533357X CHVBK 20180317142745.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1245/s10434-010-1519-9 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1519-9 Prognostic Value of Nuclear β-catenin Overexpression at Invasive Front in Colorectal Cancer for Synchronous Liver Metastasis [Elektronische Daten] [Lin Wang, Hongxia Cheng, Ying Liu, Lei Wang, Wenbin Yu, Guangyong Zhang, Bo Chen, Zhiyong Yu, Sanyuan Hu] Background: β-catenin plays an important role in colorectal tumorigenesis. Relatively little is known about the relationship between β-catenin overexpression and liver metastasis. The purpose of this study was to investigate whether nuclear β-catenin overexpression in colorectal cancer is associated with synchronous liver metastasis. Methods: The β-catenin expression in tumor tissue from 486 patients with colorectal cancer was examined by immunohistochemistry. The relationship between nuclear β-catenin expression in colorectal cancers and liver metastatic lesions and other clinicopathological characteristics was analyzed. Univariate analysis and logistic multivariate regression analysis were adopted to discriminate risk factors of liver metastasis. Results: Nuclear β-catenin overexpression at the invasive front of the primary tumor in patients with liver metastasis is more evident than that in patients without liver metastasis (71.5% vs. 29.3%; P<0.001). Nuclear β-catenin expression in primary tumors had a positive correlation with that in the matched metastatic lesions (r=0.499, P<0.001). Univariate and multivariate analyses indicated that overexpression of nuclear β-catenin at the invasive front in colorectal cancer correlated with liver metastasis. Conclusions: Overexpression of nuclear β-catenin at the invasive front in colorectal cancer is strongly associated with liver metastasis and may be a promising predictor of liver metastasis. Society of Surgical Oncology, 2011 Wang Lin Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut Cheng Hongxia Department of Pathology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China aut Liu Ying Department of Pathology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China aut Wang Lei Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut Yu Wenbin Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut Zhang Guangyong Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut Chen Bo Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut Yu Zhiyong Breast Cancer Center, Shandong Tumor Hospital and Institute, Jinan, Shandong, People's Republic of China aut Hu Sanyuan Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1553-1559 1068-9265 18:6<1553 2011 18 10434 https://doi.org/10.1245/s10434-010-1519-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1519-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Lin Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Cheng Hongxia Department of Pathology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Liu Ying Department of Pathology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Wang Lei Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Yu Wenbin Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Guangyong Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Chen Bo Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Yu Zhiyong Breast Cancer Center, Shandong Tumor Hospital and Institute, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Hu Sanyuan Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/6(2011-06-01), 1553-1559 1068-9265 18:6<1553 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer