caa a22 4500 445333618 CHVBK 20180317142745.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1245/s10434-011-1624-4 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1624-4 Surgical Prevention of Arm Lymphedema After Breast Cancer Treatment [Elektronische Daten] [Francesco Boccardo, Federico Casabona, Daniele Friedman, Maria Puglisi, Franco De Cian, Filippo Ansaldi, Corradino Campisi] Purpose: To prospectively assess the efficacy of the lymphatic microsurgical preventive healing approach (LYMPHA) to prevent lymphedema after axillary dissection (AD) for breast cancer treatment. Methods: Among 49 consecutive women referred from March 2008 to September 2009 to undergo complete AD, 46 were randomly divided in 2 groups. Twenty-three underwent the LYMPHA technique for the prevention of arm lymphedema. The other 23 patients had no preventive surgical approach (control group). The LYMPHA procedure consisted of performing lymphatic-venous anastomoses (LVA) at the time of AD. All patients underwent preoperative lymphoscintigraphy (LS). Patients were followed up clinically at 1, 3, 6, 12, and 18months by volumetry. Postoperatively, LS was performed after 18months in 41 patients (21 treatment group and 20 control group). Arm volume and LS alterations were assessed. Results: Lymphedema appeared in 1 patient in the treatment group 6months after surgery (4.34%). In the control group, lymphedema occurred in 7 patients (30.43%). No statistically significant differences in the arm volume were observed in the treatment group during follow-up, while the arm volume in the control group showed a significant increase after 1, 3, and 6months from operation. There was significant difference between the 2 groups in the volume changes with respect to baseline after 1, 3, 6, 12, and 18months after surgery (every timing P value<0.01). Conclusions: LYMPHA represents a valid technique for primary prevention of secondary arm lymphedema with no risk of leaving undetected malignant disease in the axilla. Society of Surgical Oncology, 2011 Boccardo Francesco Department of Surgery, Unit of Lymphatic Surgery, S. Martino Hospital, University of Genoa, Genoa, Italy aut Casabona Federico Department of Obstetrics and Gynecology, S. Martino Hospital, University of Genoa, Genoa, Italy aut Friedman Daniele Department of Surgery, Breast Unit, S. Martino Hospital, University of Genoa, Genoa, Italy aut Puglisi Maria Department of Surgery, Breast Unit, S. Martino Hospital, University of Genoa, Genoa, Italy aut De Cian Franco Department of Surgery, Unit of Oncologic Surgery, S. Martino Hospital, University of Genoa, Genoa, Italy aut Ansaldi Filippo Department of Health Science and Statistics, S. Martino Hospital, University of Genoa, Genoa, Italy aut Campisi Corradino Department of Surgery, Unit of Lymphatic Surgery, S. Martino Hospital, University of Genoa, Genoa, Italy aut Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2500-2505 1068-9265 18:9<2500 2011 18 10434 https://doi.org/10.1245/s10434-011-1624-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1624-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boccardo Francesco Department of Surgery, Unit of Lymphatic Surgery, S. Martino Hospital, University of Genoa, Genoa, Italy aut NATIONALLICENCE 700 1- Casabona Federico Department of Obstetrics and Gynecology, S. Martino Hospital, University of Genoa, Genoa, Italy aut NATIONALLICENCE 700 1- Friedman Daniele Department of Surgery, Breast Unit, S. Martino Hospital, University of Genoa, Genoa, Italy aut NATIONALLICENCE 700 1- Puglisi Maria Department of Surgery, Breast Unit, S. Martino Hospital, University of Genoa, Genoa, Italy aut NATIONALLICENCE 700 1- De Cian Franco Department of Surgery, Unit of Oncologic Surgery, S. Martino Hospital, University of Genoa, Genoa, Italy aut NATIONALLICENCE 700 1- Ansaldi Filippo Department of Health Science and Statistics, S. Martino Hospital, University of Genoa, Genoa, Italy aut NATIONALLICENCE 700 1- Campisi Corradino Department of Surgery, Unit of Lymphatic Surgery, S. Martino Hospital, University of Genoa, Genoa, Italy aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2500-2505 1068-9265 18:9<2500 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer