caa a22 4500 445333693 CHVBK 20180317142746.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1245/s10434-011-1658-7 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1658-7 Interrelationships between Tumor Proliferative Activity, Leucocyte and Macrophage Infiltration, Systemic Inflammatory Response, and Survival in Patients Selected for Potentially Curative Resection for Gastroesophageal Cancer [Elektronische Daten] [Andrew Crumley, James Going, Mustafa Hilmy, Sumanta Dutta, Claire Tannahill, Margaret McKernan, Joanne Edwards, Robert Stuart, Donald McMillan] Background: A number of accepted criteria, including pathological tumor, node, metastasis system stage, lymph node metastasis, and tumor differentiation, predict survival in patients undergoing surgery for gastroesophageal cancer. We examined the interrelationships between standard clinicopathological factors, systemic and local inflammatory responses, tumor proliferative activity, and survival. Methods: The interrelationships between the systemic inflammatory response (Glasgow prognostic score, mGPS), standard clinicopathological factors, local inflammatory response (Klintrup criteria, macrophage infiltration), and tumor proliferative activity (Ki-67) were examined by immunohistochemistry in 100 patients (44 esophageal [19 squamous, 25 adenocarcinoma], 19 junctional, and 37 gastric cancers) selected for potentially curative resection. Results: The minimum follow-up was 59months. On multivariate survival analysis, lymph node ratio (hazard ratio [HR] 1.63, 95% confidence interval [CI] 1.11-2.40, P<0.05), tumor differentiation (HR 2.63, 95% CI 1.45-4.77, P=0.001), mGPS (HR 3.91, 95% CI 1.96-8.11, P<0.001), Klintrup score (HR 3.47, 95% CI 1.14-10.55, P<0.05), and Ki-67 (HR 0.67, 95% CI 0.47-0.96, P<0.05) were independently associated with cancer-specific survival. A higher lymph node ratio was associated with poor tumor differentiation (P<0.05), low-grade Klintrup criteria (P<0.005), and low tumor proliferative activity (P<0.05). Conclusion: Tumor proliferation rate and local and systemic inflammatory responses are important predictors of survival, albeit in a heterogeneous cohort of patients including esophageal, junctional, and gastric cancers. These scores may be combined with accepted tumor-based factors to improve prediction of outcome. Society of Surgical Oncology, 2011 Crumley Andrew University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut Going James University Department of Pathology, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut Hilmy Mustafa University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut Dutta Sumanta University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut Tannahill Claire University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut McKernan Margaret University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut Edwards Joanne University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut Stuart Robert University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut McMillan Donald University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2604-2612 1068-9265 18:9<2604 2011 18 10434 https://doi.org/10.1245/s10434-011-1658-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1658-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Crumley Andrew University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Going James University Department of Pathology, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Hilmy Mustafa University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Dutta Sumanta University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Tannahill Claire University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- McKernan Margaret University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Edwards Joanne University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Stuart Robert University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- McMillan Donald University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2604-2612 1068-9265 18:9<2604 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer