caa a22 4500 445333723 CHVBK 20180317142746.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1245/s10434-011-1655-x doi (NATIONALLICENCE)springer-10.1245/s10434-011-1655-x Evaluation of 18F-FDG PET/CT and CT/MRI with Histopathologic Correlation in Patients Undergoing Salvage Surgery for Head and Neck Squamous Cell Carcinoma [Elektronische Daten] [Sang Kim, Jae Kim, Jong Yi, Jeong Lee, Seung-Ho Choi, Soon Nam, Kyung-Ja Cho, Sang-wook Lee, Sung-Bae Kim, Jong-Lyel Roh] Background: 18F-fludeoxyglucose (FDG) positron emission tomography (PET) is a sensitive and specific method for detecting active residual disease after chemoradiotherapy or radiotherapy, but few studies have accurately evaluated its diagnostic accuracy with histopathologic correlation. We therefore investigated the clinical utility of 18F-FDG PET/computed tomography (CT) in patients undergoing salvage surgery for residual head and neck squamous cell carcinoma (HNSCC) after primary nonsurgical treatments. Methods: Thirty-nine patients who initially received chemotherapy (n=23), radiotherapy (n=3), or chemoradiotherapy (n=13) were evaluated 8-28weeks later by 18F-FDG PET/CT and CT/magnetic resonance imaging (MRI) prior to salvage surgery to clear residual disease. These results were compared with those of histopathologic analysis of the primary tumor and neck dissection tissue samples. Results: Of these 39 patients, 22 (56%) had residual primary tumor. The sensitivity, specificity and accuracy of 18F-FDG PET/CT for detecting primary tumors were 91, 65, and 79%, respectively. Of 56 dissected heminecks, 37 (66%) had residual metastatic lymph nodes. 18F-FDG PET/CT and CT/MRI had accuracies for positive heminecks of 91 and 75%, respectively (P=0.004). On a cervical level-by-level-based analysis, 18F-FDG PET/CT and CT/MRI had accuracies of 89 and 78%, respectively (P<0.001); 18F-FDG PET/CT had a specificity of 93% and a negative-predictive value of 92% for detection of positive levels. Conclusions: 18F-FDG PET/CT is superior to CT/MRI in detecting residual nodal disease in head and neck squamous cell carcinoma patients undergoing salvage surgery. Accurate preoperative diagnosis using 18F-FDG PET/CT may help to determine the extent of salvage surgery. Society of Surgical Oncology, 2011 Kim Sang Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Kim Jae Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Yi Jong Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Lee Jeong Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Choi Seung-Ho Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Nam Soon Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Cho Kyung-Ja Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Lee Sang-wook Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Kim Sung-Bae Department of Internal Medicine (Oncology), Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Roh Jong-Lyel Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2579-2584 1068-9265 18:9<2579 2011 18 10434 https://doi.org/10.1245/s10434-011-1655-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1655-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Sang Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Jae Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Yi Jong Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Jeong Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Choi Seung-Ho Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Nam Soon Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Cho Kyung-Ja Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Sang-wook Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Sung-Bae Department of Internal Medicine (Oncology), Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Roh Jong-Lyel Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2579-2584 1068-9265 18:9<2579 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer