caa a22 4500 445333790 CHVBK 20180317142746.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1245/s10434-011-1617-3 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1617-3 Papillary Lesions Initially Diagnosed at Ultrasound-guided Vacuum-assisted Breast Biopsy: Rate of Malignancy Based on Subsequent Surgical Excision [Elektronische Daten] [Jung Chang, Wonsik Han, Woo Moon, Nariya Cho, Dong-Young Noh, In-Ae Park, Eun-Jung Jung] Purpose: To prospectively determine the rate of malignancy after surgery in papillary lesions initially diagnosed at ultrasound (US)-guided 11-gauge vacuum-assisted breast biopsies. Methods: Between May 2007 and December 2009, a total of 85 papillary lesions, including 73 benign papillomas and 12 atypical papillomas were diagnosed in 83 patients by US-guided 11-gauge vacuum-assisted breast biopsy. Surgical excision was recommended for all patients and 60 nonmalignant papillary lesions (49 benign papillomas and 11 atypical papillomas) in 60 patients (age range, 24-66years; mean age, 45.0years) were surgically excised. On a per-lesion basis, the upgrade rate to malignancy was calculated. Associations between clinical, lesion, and biopsy variables and the results of surgical excision were examined with a χ2 test. Results: Surgical excision revealed the presence of benign papillomas in 34 cases, no residual lesion in 15 cases, atypical papillomas in nine cases, and ductal carcinoma-in-situ in two cases. The upgrade rate was 0% (0 of 49; 95% confidence interval 0-7.2) for benign papillomas and 18.2% (2 of 11; 95% confidence interval 2.3-51.8) for atypical papillomas. The core findings of atypical papillomas (P=0.031) and age (P=0.046) were associated with malignancy at excision, whereas personal or family history, presence of symptoms, multiplicity, lesion type, size, distance from the nipple, Breast Imaging Reporting and Data System (BI-RADS) category, and lesion removal at US showed no correlation to upgrade. Conclusions: Surgical excision may not be required for lesions with a diagnosis of benign papilloma after US-guided 11-gauge vacuum-assisted breast biopsy, and a diagnosis of atypical papilloma should prompt excision for a definitive diagnosis. Society of Surgical Oncology, 2011 Chang Jung Department of Radiology, Seoul National University Hospital, Seoul, Korea aut Han Wonsik Department of Surgery, Seoul National University Hospital, Seoul, Korea aut Moon Woo Department of Radiology, Seoul National University Hospital, Seoul, Korea aut Cho Nariya Department of Radiology, Seoul National University Hospital, Seoul, Korea aut Noh Dong-Young Department of Surgery, Seoul National University Hospital, Seoul, Korea aut Park In-Ae Department of Pathology, Seoul National University Hospital, Seoul, Korea aut Jung Eun-Jung Department of Pathology, Seoul National University Hospital, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2506-2514 1068-9265 18:9<2506 2011 18 10434 https://doi.org/10.1245/s10434-011-1617-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1617-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chang Jung Department of Radiology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Han Wonsik Department of Surgery, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Moon Woo Department of Radiology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Cho Nariya Department of Radiology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Noh Dong-Young Department of Surgery, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Park In-Ae Department of Pathology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Jung Eun-Jung Department of Pathology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2506-2514 1068-9265 18:9<2506 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer