caa a22 4500 445333804 CHVBK 20180317142746.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1245/s10434-011-1651-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1651-1 Closed Abdomen Hyperthermic Intraperitoneal Chemotherapy with Irinotecan and Mitomycin C: a Phase I Study [Elektronische Daten] [Eddy Cotte, Guillaume Passot, Michel Tod, Naoual Bakrin, François-Noël Gilly, Aline Steghens, Faheez Mohamed, Olivier Glehen] Purpose: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is now a recognized treatment for peritoneal carcinomatosis (PC). The objective of this phase I study is to determine the maximum tolerated dose of irinotecan (CPT-11) when used with mitomycin C (MMC) for closed abdomen HIPEC. Methods: Patients with PC fulfilling the inclusion criteria were studied. All underwent cytoreductive surgery and closed abdomen HIPEC with 0.7mg/kg MMC and an escalating dose of irinotecan. Grade 4 (National Cancer Institute grading system) surgical and hematological complications were used to identify dose-limiting toxicity (DLT). Results: 12 patients were studied. At the first dose level of irinotecan (100mg/m2), one patient developed a grade 4 hematological toxicity. Three other patients were included at the same level with no toxicity. Three patients were then included at the second dose level (150mg/m2 irinotecan), of whom one developed a grade 4 surgical complication. Three further patients were thus included at the second dose level. Of these three, two patients developed DLT [grade 4 neutropenia in one, grade 4 neutropenia and thrombocytopenia with an intra-abdominal lymphatic fistula requiring reoperation (grade 4 surgical complication) in the other]. Dose escalation was stopped at this level. The maximum tolerated dose of irinotecan was determined to be 100mg/m2. Conclusion: Closed HIPEC combining MMC and irinotecan is safe and feasible. For HIPEC, the maximum tolerated dose of irinotecan is 100mg/m2 when used with 0.7mg/kg MMC. Society of Surgical Oncology, 2011 Cotte Eddy Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut Passot Guillaume Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut Tod Michel EA 3738, Faculté de Médecine Lyon Sud, Université Claude Bernard Lyon1, Oullins cedex, France aut Bakrin Naoual Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut Gilly François-Noël Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut Steghens Aline Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut Mohamed Faheez Colorectal Research Unit, Basingstoke and North Hampshire Foundation Trust, Basingstoke, UK aut Glehen Olivier Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2599-2603 1068-9265 18:9<2599 2011 18 10434 https://doi.org/10.1245/s10434-011-1651-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1651-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cotte Eddy Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut NATIONALLICENCE 700 1- Passot Guillaume Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut NATIONALLICENCE 700 1- Tod Michel EA 3738, Faculté de Médecine Lyon Sud, Université Claude Bernard Lyon1, Oullins cedex, France aut NATIONALLICENCE 700 1- Bakrin Naoual Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut NATIONALLICENCE 700 1- Gilly François-Noël Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut NATIONALLICENCE 700 1- Steghens Aline Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut NATIONALLICENCE 700 1- Mohamed Faheez Colorectal Research Unit, Basingstoke and North Hampshire Foundation Trust, Basingstoke, UK aut NATIONALLICENCE 700 1- Glehen Olivier Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Hospices Civils de Lyon, Pierre Bénite cedex, France aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2599-2603 1068-9265 18:9<2599 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer