caa a22 4500 445333863 CHVBK 20180317142746.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1245/s10434-011-1609-3 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1609-3 Association of Intra-tumoral Infiltrating Macrophages and Regulatory T Cells Is an Independent Prognostic Factor in Gastric Cancer after Radical Resection [Elektronische Daten] [Bo Wang, Dazhi Xu, Xingjuan Yu, Tong Ding, Huilan Rao, Youqing Zhan, Limin Zheng, Lian Li] Background: Macrophages (Mφ) and regulatory T cells (Tregs) are the major components of the inflammatory infiltrate in virtually all tumors. The objective of this study was to investigate the prognostic significance of Mφ and Tregs infiltration in advanced gastric cancer after radical resection. Methods: CD68+ Mφ and FOXP3+ Tregs were assessed by immunohistochemistry in tissues from 107 patients with surgically advanced gastric cancer. The microlocalization of Mφ and Tregs cells with respect to the development of gastric cancer were given special concern. Prognostic value of normal, peritumoral, and intratumoral Mφ and Tregs densities was evaluated by Kaplan-Meier analysis and Cox regression. Results: The results showed that the presence of intratumoral CD68+ Mφ was an independent prognostic factor for overall survival (OS) (P=0.02). Moreover, the combination of high numbers of intratumoral CD68+ Mφ and FOXP3+ Tregs was associated with improved survival (P=0.041). Five-year OS rate was only 27% for patients with low intratumoral Mφ and intratumoral Tregs compared with 62% for patients with high intratumoral Mφ and intratumoral Tregs. In addition, advanced intestinal-type gastric cancers were more likely to have fewer infiltrating Mφ than diffuse-type cancers (P=0.024). Conclusions: Association of intratumoral Mφ and Tregs is a promising independent predictor for survival in advanced gastric cancer. The results suggested that a combination of concomitant stimulation of intratumoral Mφ and Tregs may be an effective strategy for treatment of patients with advanced gastric cancer after radical resection. Society of Surgical Oncology, 2011 Wang Bo State Key Laboratory of Biocontrol, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut Xu Dazhi State Key Laboratory of Oncology in South China, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut Yu Xingjuan State Key Laboratory of Oncology in South China, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut Ding Tong State Key Laboratory of Oncology in South China, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut Rao Huilan Department of Pathology, Cancer Center, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut Zhan Youqing State Key Laboratory of Oncology in South China, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut Zheng Limin State Key Laboratory of Biocontrol, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut Li Lian State Key Laboratory of Biocontrol, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2585-2593 1068-9265 18:9<2585 2011 18 10434 https://doi.org/10.1245/s10434-011-1609-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1609-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Bo State Key Laboratory of Biocontrol, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Xu Dazhi State Key Laboratory of Oncology in South China, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Yu Xingjuan State Key Laboratory of Oncology in South China, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Ding Tong State Key Laboratory of Oncology in South China, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Rao Huilan Department of Pathology, Cancer Center, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zhan Youqing State Key Laboratory of Oncology in South China, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zheng Limin State Key Laboratory of Biocontrol, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Li Lian State Key Laboratory of Biocontrol, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2585-2593 1068-9265 18:9<2585 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer