caa a22 4500 445333898 CHVBK 20180317142746.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1245/s10434-011-1637-z doi (NATIONALLICENCE)springer-10.1245/s10434-011-1637-z Impact of Obesity on Operative Morbidity and Clinical Outcome in Primary Epithelial Ovarian Cancer after Optimal Primary Tumor Debulking [Elektronische Daten] [Christina Fotopoulou, Rolf Richter, Elena-Ioana Braicu, Marc Kuhberg, Aarne Feldheiser, Joerg Schefold, Werner Lichtenegger, Jalid Sehouli] Background: Obesity is a common and increasing condition in Western countries and seems to be associated with increased carcinogenesis and tumor invasiveness. We evaluated operative and clinical outcome in patients operated to treat primary epithelial ovarian cancer (EOC) according to their body mass index (BMI). Methods: All consecutive EOC patients who underwent cytoreductive surgery in our institution between September 2000 and April 2010 were systematically evaluated according to their BMI (kg/m2). Survival was calculated by Kaplan-Meier curves. Logistic regression and Cox regression analysis were performed to identify the impact of obesity on surgical outcome and survival. Results: Three hundred six patients were evaluated. A total of 40.2% were classified as overweight; 87 (28.4%) had a BMI of 25-30kg/m2 and 36 (11.8%) had a BMI of ≥30kg/m2. No statistically significant differences regarding tumor-related characteristics and comorbidities existed between normal-weight and overweight patients. Median operation time was significantly longer (P=0.024) in overweight versus normal-weight patients (280min; range 40-529 vs. 257min; range 32-592, respectively). Complete tumor resection rates were equivalent between the two patient groups (68.6% vs. 72.5%; P=0.543) with similar median overall and progression-free survival in both groups (43 vs. 42months and 21 vs. 17.8months, respectively). Operative morbidity was also not significantly different between the two groups. By comparable morbidity, operative procedures were similar between normal-weight and overweight patients, apart from higher intestinal and diaphragmatic resection rates in the overweight patients (61% vs. 43.7%; P=0.004 and 24.4% vs. 14.2%; P=0.034). In multivariate analysis, BMI of ≥25kg/m2 did not reveal any prognostic significance in respect of survival, operative morbidity, and complete tumor resection. Conclusions: BMI does not appear to influence tumor stage, histology, differentiation grade, or tumor marker levels in patients with primary EOC. Also, BMI is not an independent predictive and prognostic marker of survival, operative outcome, or morbidity at the time of primary tumor debulking. Society of Surgical Oncology, 2011 Fotopoulou Christina Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut Richter Rolf Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut Braicu Elena-Ioana Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut Kuhberg Marc Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut Feldheiser Aarne Klinik für Anästhesiologie und Operative Intensivmedizin, Charité-Universitätsmedizin Berlin, Berlin, Germany aut Schefold Joerg Department of Nephrology and Intensive Care, Charité Medical University of Berlin, Berlin, Germany aut Lichtenegger Werner Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut Sehouli Jalid Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2629-2637 1068-9265 18:9<2629 2011 18 10434 https://doi.org/10.1245/s10434-011-1637-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1637-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fotopoulou Christina Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut NATIONALLICENCE 700 1- Richter Rolf Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut NATIONALLICENCE 700 1- Braicu Elena-Ioana Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut NATIONALLICENCE 700 1- Kuhberg Marc Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut NATIONALLICENCE 700 1- Feldheiser Aarne Klinik für Anästhesiologie und Operative Intensivmedizin, Charité-Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Schefold Joerg Department of Nephrology and Intensive Care, Charité Medical University of Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Lichtenegger Werner Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut NATIONALLICENCE 700 1- Sehouli Jalid Department of Gynecology, European Competence Center for Ovarian Cancer, Charité University-Hospital, Berlin, Germany aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/9(2011-09-01), 2629-2637 1068-9265 18:9<2629 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer