caa a22 4500 445334037 CHVBK 20180317142747.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-010-1510-5 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1510-5 Overexpression of Metastasis-Associated Protein 1 is Significantly Correlated with Tumor Angiogenesis and Poor Survival in Patients with Early-Stage Non-Small Cell Lung Cancer [Elektronische Daten] [Shu-hai Li, Hui Tian, Wei-ming Yue, Lin Li, Wen-jun Li, Zhi-tao Chen, Wen-si Hu, Ying-chao Zhu, Lei Qi] Background: The aims of this work are to detect the expression levels of metastasis-associated protein 1 (MTA1) in patients with early-stage non-small cell lung cancer (NSCLC), and to investigate the relationship of MTA1 protein with clinicopathologic factors, tumor angiogenesis, and prognosis. Methods: One hundred and two patients with pathologic stage I NSCLC who successfully underwent curative surgical resection were enrolled in this study. Immunohistochemical staining for MTA1 and CD34 was performed using the streptavidin-peroxidase method, and intratumoral microvessel density (MVD) was recorded by counting CD34-positive immunostained endothelial cells. All statistical analyses were performed with SPSS statistical software to determine the effects of MTA1 protein on clinicopathologic factors, tumor angiogenesis, and prognosis. Results: MTA1 protein overexpression was detected in 41 cases and was significantly associated with MVD (P=0.008). MTA1 protein overexpression and high MVD were significantly associated with tumor relapse (P=0.004 and 0.007) and poor 5-year disease-free survival (P=0.001 and 0.004). Patients with MTA1 protein overexpression and high MVD had significantly poor overall survival (P=0.005 and 0.043) and disease-specific survival (P=0.006 and 0.031) at 5years after operation. Multivariate analysis demonstrated that MTA1 protein overexpression was an independent prognosticator for unfavorable disease-free, overall, and disease-specific survival (P=0.011, 0.024, and 0.046). Conclusions: MTA1 protein overexpression is common in early-stage NSCLC and is significantly associated with tumor angiogenesis and poor survival. These findings suggest that MTA1 may have clinical potential as a promising predictor to identify individuals with poor prognostic potential and as a possible novel target molecule of antiangiogenic therapy for patients with early-stage NSCLC. Society of Surgical Oncology, 2011 Li Shu-hai Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut Tian Hui Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut Yue Wei-ming Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut Li Lin Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut Li Wen-jun Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut Chen Zhi-tao Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, China aut Hu Wen-si Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut Zhu Ying-chao Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut Qi Lei Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 2048-2056 1068-9265 18:7<2048 2011 18 10434 https://doi.org/10.1245/s10434-010-1510-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1510-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Shu-hai Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Tian Hui Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Yue Wei-ming Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Li Lin Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Li Wen-jun Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Chen Zhi-tao Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Hu Wen-si Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Zhu Ying-chao Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Qi Lei Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 2048-2056 1068-9265 18:7<2048 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer