caa a22 4500 445334045 CHVBK 20180317142747.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-010-1526-x doi (NATIONALLICENCE)springer-10.1245/s10434-010-1526-x Surgical Treatment of Renal Cell Cancer Liver Metastases: A Population-Based Study [Elektronische Daten] [Anthony Ruys, Pieter Tanis, Nagtegaal Iris, Peter van Duijvendijk, Cornelis Verhoef, Robert Porte, Thomas van Gulik] Background: To evaluate outcomes of surgical treatment in patients with hepatic metastases from renal-cell carcinoma in the Netherlands, and to identify prognostic factors for survival after resection. Renal-cell carcinoma has an incidence of 2,000 new patients in the Netherlands each year (12.5/100,000 inhabitants). According to literature, half of these patients ultimately develop distant metastases with 20% involvement of the liver. Resection of renal-cell carcinoma liver metastases (RCCLM) is performed in only a minority of patients. Hence, little is known about outcome of resectable RCCLM. Methods: Patients were retrieved from local databases of theNetherlands Task Force for Liver Surgery (14 centers) and from the Dutch collective pathology database. Survival and prognostic factors were determined by Kaplan-Meier analysis and log rank test. Results: Thirty-three patients were identified who underwent resection (n=29) or local ablation (n=4) of RCCLM in the Netherlands between 1990 and 2008. These patients comprise 0.5% to 1% of the total population of patients diagnosed with RCCLM in that period. There was no operative mortality. The overall survival at 1, 3, and 5years was 79, 47, and 43%, respectively. Metachronous metastases (n=23, P=0.03) and radical resection (n=19, P<0.001) were statistically significant prognosticators of overall survival. Size<50mm (n=18, P=0,54), solitary metastases (n=19, P=0.93), and presence of extrahepatic metastases (n=11, P=0.28) did not have a statistically significant impact on survival. Conclusions: The favorable 5-year survival rate of 43% without operative mortality as found in this nationwide study indicates that selected patients with RCCLM can benefit from surgical treatment. The Author(s), 2011 Ruys Anthony Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands aut Tanis Pieter Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands aut Iris Nagtegaal Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands aut van Duijvendijk Peter Department of Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands aut Verhoef Cornelis Department of Surgery, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands aut Porte Robert Department of Surgery, University Medical Centre Groningen, Groningen, The Netherlands aut van Gulik Thomas Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1932-1938 1068-9265 18:7<1932 2011 18 10434 https://doi.org/10.1245/s10434-010-1526-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1526-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ruys Anthony Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Tanis Pieter Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Iris Nagtegaal Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- van Duijvendijk Peter Department of Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Verhoef Cornelis Department of Surgery, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Porte Robert Department of Surgery, University Medical Centre Groningen, Groningen, The Netherlands aut NATIONALLICENCE 700 1- van Gulik Thomas Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1932-1938 1068-9265 18:7<1932 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer