caa a22 4500 445334096 CHVBK 20180317142747.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-010-1468-3 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1468-3 Poorer Survival Outcomes for Male Breast Cancer Compared with Female Breast Cancer May Be Attributable to In-Stage Migration [Elektronische Daten] [Jennifer Gnerlich, Anjali Deshpande, Donna Jeffe, Susmitha Seelam, Eric Kimbuende, Julie Margenthaler] Background: Male breast cancer accounts for less than 1% of all breast cancers, yet males have a worse prognosis than females with breast cancer. Methods: Using the 1988-2003 Surveillance, Epidemiology, and End Results Program data, we conducted a retrospective, population-based cohort study to investigate stage-specific differences in breast cancer-specific and all-cause mortality between males and females. We calculated adjusted hazard ratios (aHR) and 95% confidence intervals (CI) using Cox regression models to compare breast cancer-specific and all-cause mortality by stage between males and females, controlling for potential confounding variables. Results: There were 246,059 patients with a first, single, primary breast cancer [1,541 (0.6%) male; 244,518 (99.4%) female]. Compared with females, males were more likely to be older, Black, married, diagnosed at more advanced stages, and treated with mastectomy (each P<0.001). Males also were more likely to have lower grade and estrogen/progesterone receptor-positive tumors (each P<0.001). After controlling for confounders, males were more likely to die from their breast cancer when compared with females, only if diagnosed with stage I disease (aHR 1.72, CI 1.15-2.61). For all-cause mortality, males were more likely than females to die at each stage of disease except stage IV. Conclusions: Although all-cause mortality was higher for men than women at all stages of nonmetastatic breast cancer, higher male breast cancer-specific mortality was attributed to poorer survival in stage I disease. However, this statistical difference is unlikely to be clinically relevant and attributable to in-stage migration. Society of Surgical Oncology, 2010 Gnerlich Jennifer Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Deshpande Anjali Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA aut Jeffe Donna Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA aut Seelam Susmitha Department of Community Health, Saint Louis University School of Public Health, St. Louis, MO, USA aut Kimbuende Eric Department of Community Health, Saint Louis University School of Public Health, St. Louis, MO, USA aut Margenthaler Julie Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1837-1844 1068-9265 18:7<1837 2011 18 10434 https://doi.org/10.1245/s10434-010-1468-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1468-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gnerlich Jennifer Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Deshpande Anjali Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Jeffe Donna Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Seelam Susmitha Department of Community Health, Saint Louis University School of Public Health, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Kimbuende Eric Department of Community Health, Saint Louis University School of Public Health, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Margenthaler Julie Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1837-1844 1068-9265 18:7<1837 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer