caa a22 4500 44533410X CHVBK 20180317142747.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-011-1559-9 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1559-9 Polymorphism in Epidermal Growth Factor Receptor Intron 1 Predicts Prognosis of Patients with Esophageal Cancer after Chemoradiation and Surgery [Elektronische Daten] [Jang-Ming Lee, Shi-Yi Yang, Pei-Wen Yang, Chia-Tung Shun, Ming-Tsang Wu, Chih-Hung Hsu, Chia-Chi Lin, Jason Cheng, Ying-Hao Wang, Tzu-Hsuen Chuang, Jin-Shing Chen, Hsao-Hsun Hsu, Pei-Ming Huang, Shuenn-Wen Kuo, Yung-Chie Lee] Background: The EGFR gene has been demonstrated to be an important factor influencing treatment response for various cancers, and its expression has been shown to be modified by the polymorphic CA repeat length at the 5′-regulatory sequence in intron 1. We investigated whether this EGFR polymorphism is associated with prognosis in patients with esophageal cancer after concurrent chemoradiotherapy (CCRT) and esophagectomy. Methods: A cohort of 148 patients with esophageal cancer received cisplatin-based CCRT (concurrently combined with 40Gy irradiation) and subsequent esophagectomy. Their EGFR genotypes were determined by polymerase chain reaction from leukocyte DNA, which was obtained before treatment and was correlated with patient survival. Results: Patients with the homozygous short allele (<20 CA) of the EGFR gene in intron 1 were more likely to have a shorter duration of survival after CCRT and surgery than those with the homozygous long allele [adjusted hazard ratio (HR) (95% confidence interval [CI]) of death: 1.88 (1.02-3.49); P=0.045]. This unfavorable prognostic effect of EGFR homozygous short CA repeat was mainly manifested in patients with good response to CCRT [adjusted HR (95% CI) of death 3.40 (1.06-10.89); P=0.039]; it was less evident in those with poor response to CCRT [adjusted HR (95% CI) 1.40 (0.65-3.02); P=0.384]. Conclusions: The EGFR CA repeat genetic polymorphism may act as a valuable molecular predictor of clinical outcome of esophageal cancer after CCRT and esophagectomy, especially in those with good response to CCRT. Society of Surgical Oncology, 2011 Lee Jang-Ming Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Yang Shi-Yi Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan aut Yang Pei-Wen Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Shun Chia-Tung Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan aut Wu Ming-Tsang Department of Family Medicine, Graduate Institute of Occupational Safety and Health, Kaohsiung, Taiwan aut Hsu Chih-Hung Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan aut Lin Chia-Chi Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan aut Cheng Jason Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan aut Wang Ying-Hao Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Chuang Tzu-Hsuen Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Chen Jin-Shing Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Hsu Hsao-Hsun Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Huang Pei-Ming Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Kuo Shuenn-Wen Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Lee Yung-Chie Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 2066-2073 1068-9265 18:7<2066 2011 18 10434 https://doi.org/10.1245/s10434-011-1559-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1559-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Jang-Ming Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Yang Shi-Yi Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Yang Pei-Wen Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Shun Chia-Tung Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wu Ming-Tsang Department of Family Medicine, Graduate Institute of Occupational Safety and Health, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Hsu Chih-Hung Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lin Chia-Chi Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Cheng Jason Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wang Ying-Hao Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chuang Tzu-Hsuen Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chen Jin-Shing Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Hsu Hsao-Hsun Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Huang Pei-Ming Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Kuo Shuenn-Wen Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lee Yung-Chie Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 2066-2073 1068-9265 18:7<2066 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer