caa a22 4500 445334134 CHVBK 20180317142747.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-010-1546-6 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1546-6 Dynamic Sentinel Node Biopsy for Inguinal Lymph Node Staging in Patients with Penile Cancer: A Systematic Review and Cumulative Analysis of the Literature [Elektronische Daten] [Ary Neto, Marcos Tobias-Machado, Vincenzo Ficarra, Marcelo Wroclawski, Rodrigo Amarante, Antônio Pompeo, Auro Giglio] Background: Dynamic sentinel node biopsy (DSNB) is used to evaluate the nodal status of patients with clinically node-negative penile carcinoma. Its use is not widespread, and the majority of patients with clinically node-negative disease undergo an elective inguinal lymph node dissection (ILND). However, a prophylactic bilateral ILND is a procedure with approximately 50% of morbidity. The purpose of this review is to evaluate the accuracy of DSNB in penile cancer. Methods: This is a systematic review and cumulative analysis of studies published between 1966 and 2010. The Medline, Embase, Cancerlit, and American Society of Clinical Oncology abstract databases were searched for published studies on penile cancer and DSNB. The outcomes assessed were: sensitivity, specificity, likelihood ratios, and summary receiver operating characteristics (ROC) curves. Results: Ten articles covering 519 participants were included in the cumulative analysis. The pooled sensitivities and specificities for sentinel node biopsy for detection of metastasis were 77.1 and 100% versus ILND and 87.9 and 100% versus wait and see program. The false-negative rate founded was 3.1% in the ILND group and 3.5% in the wait and see group. Conclusions: The use of dynamic sentinel lymph node biopsy to detect lymph node metastasis in specialized centers appears to be justified. Addiction of other techniques to DSNB to reduce false-negative results is awaited and must be confirmed by future studies. Society of Surgical Oncology, 2011 Neto Ary Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut Tobias-Machado Marcos Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut Ficarra Vincenzo Department of Oncological and Surgical Sciences, Urology Clinic, University of Padua, Padua, Italia aut Wroclawski Marcelo Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut Amarante Rodrigo Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut Pompeo Antônio Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut Giglio Auro Research Institute—Albert Einstein Jewish Hospital (IEP-HIAE), São Paulo, Brazil aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 2026-2034 1068-9265 18:7<2026 2011 18 10434 https://doi.org/10.1245/s10434-010-1546-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1546-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Neto Ary Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut NATIONALLICENCE 700 1- Tobias-Machado Marcos Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut NATIONALLICENCE 700 1- Ficarra Vincenzo Department of Oncological and Surgical Sciences, Urology Clinic, University of Padua, Padua, Italia aut NATIONALLICENCE 700 1- Wroclawski Marcelo Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut NATIONALLICENCE 700 1- Amarante Rodrigo Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut NATIONALLICENCE 700 1- Pompeo Antônio Urologic Oncology Division, Department of Urology, ABC Medical School (FMABC), Santo Andre, Brazil aut NATIONALLICENCE 700 1- Giglio Auro Research Institute—Albert Einstein Jewish Hospital (IEP-HIAE), São Paulo, Brazil aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 2026-2034 1068-9265 18:7<2026 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer