caa a22 4500 445334223 CHVBK 20180317142748.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-011-1556-z doi (NATIONALLICENCE)springer-10.1245/s10434-011-1556-z Minimal Extrathyroidal Extension in Patients with Papillary Thyroid Microcarcinoma: Is It a Real Prognostic Factor? [Elektronische Daten] [Hee Moon, Eun-Kyung Kim, Woong Chung, Jung Yoon, Jin Kwak] Background: The clinical impact of minimal extrathyroidal extension (ETE) in patients with conventional papillary thyroid microcarcinoma (PTMC) is still controversial. The clinicopathologic characteristics of patients with or without minimal ETE or recurrence and the clinical impact of minimal ETE were investigated. Methods: This study included 288 patients with conventional PTMC (mean age, 46.6years; 262 female and 26 male subjects) and more than 5years of follow-up. Patients were divided into two groups according to ETE and recurrence, and clinicopathologic characteristics between two groups were investigated. Disease-free survival was calculated to compare the clinical impact of minimal ETE between patients with and without ETE. Results: Mean size (6.9mm) of PTMCs in patients with minimal ETE (n=89) was significantly larger than that in those (5.8mm) without (n=199) (P<0.001). Tumor size [odds ratio (OR)=1.185; 95% confidence interval (CI) 1.052-1.334], central lymph node (LN) metastasis at diagnosis (OR 2.105; 95% CI 1.182-3.750), and not well-defined margin on ultrasound (OR 3.808; 95% CI 1.055-13.736) were significantly associated with minimal ETE. Twelve patients (4.2%) had recurrence. No clinicopathologic factor was associated with recurrence. Disease-free survival was not significantly different between patients with and without minimal ETE (P=0.671). Conclusions: Minimal ETE was statistically significantly associated with tumor size, central LN metastasis, and not well-defined margin on ultrasound. Minimal ETE had no impact on recurrence in patients with conventional PTMC. Society of Surgical Oncology, 2011 Moon Hee Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut Kim Eun-Kyung Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut Chung Woong Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Yoon Jung Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut Kwak Jin Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1916-1923 1068-9265 18:7<1916 2011 18 10434 https://doi.org/10.1245/s10434-011-1556-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1556-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moon Hee Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Eun-Kyung Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Chung Woong Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Yoon Jung Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kwak Jin Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1916-1923 1068-9265 18:7<1916 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer