caa a22 4500 445334266 CHVBK 20180317142748.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-011-1551-4 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1551-4 Prognosis of Hepatocellular Carcinoma in Relation to Treatment Across BCLC Stages [Elektronische Daten] [Delia D'Avola, Mercedes Iñarrairaegui, Fernando Pardo, Fernando Rotellar, Pablo Marti, José Bilbao, Antonio Martinez-Cuesta, Alberto Benito, Felix Alegre, Erica Mauleón, José Herrero, Jorge Quiroga, Jesus Prieto, Bruno Sangro] Background: The Barcelona Clinic Liver Cancer (BCLC) staging system recommends first-line therapy for each tumor stage. We evaluated the effect of compliance with BCLC treatment allocation on the prognosis of patients with hepatocellular carcinoma (HCC). Methods: We retrospectively analyzed 359 consecutive, newly diagnosed HCC patients treated in our Liver Unit during a 14-year period. For each stage, survival was compared according to whether treatment matched the BCLC recommendation. We also compared the survival of patients in the same BCLC stage who received different treatments, and patients in different BCLC stages receiving the same treatment. Results: BCLC-A patients treated with radical therapies (66%) survived longer (117 vs. 20months; p<0.001) than patients (33%) who received locoregional or systemic therapies. Survival of BCLC-B patients treated with locoregional treatments (57%) was shorter (24 vs. 71months; p<0.001) than that of patients receiving radical therapies (32%). BCLC-C patients treated with systemic therapy or supportive care survived shorter (6 vs. 11months; p=0.003) than those receiving locoregional therapies (39%). Survival of BCLC-D patients receiving systemic therapies or supportive care was significantly lower than that of patients treated by liver transplantation (5 vs. 137months; p<0.001). Conclusions: In addition to BCLC stage, actual treatment determines survival in patients with HCC. Society of Surgical Oncology, 2011 D'Avola Delia Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut Iñarrairaegui Mercedes Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut Pardo Fernando Department of Hepatobiliary Surgery, Clinica Universitaria de Navarra, Pamplona, Spain aut Rotellar Fernando Department of Hepatobiliary Surgery, Clinica Universitaria de Navarra, Pamplona, Spain aut Marti Pablo Department of Hepatobiliary Surgery, Clinica Universitaria de Navarra, Pamplona, Spain aut Bilbao José Department of Radiology, Clinica Universitaria de Navarra, Pamplona, Spain aut Martinez-Cuesta Antonio Department of Radiology, Clinica Universitaria de Navarra, Pamplona, Spain aut Benito Alberto Department of Radiology, Clinica Universitaria de Navarra, Pamplona, Spain aut Alegre Felix Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut Mauleón Erica Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut Herrero José Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut Quiroga Jorge Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut Prieto Jesus Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut Sangro Bruno Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1964-1971 1068-9265 18:7<1964 2011 18 10434 https://doi.org/10.1245/s10434-011-1551-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1551-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- D'Avola Delia Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Iñarrairaegui Mercedes Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Pardo Fernando Department of Hepatobiliary Surgery, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Rotellar Fernando Department of Hepatobiliary Surgery, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Marti Pablo Department of Hepatobiliary Surgery, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Bilbao José Department of Radiology, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Martinez-Cuesta Antonio Department of Radiology, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Benito Alberto Department of Radiology, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Alegre Felix Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Mauleón Erica Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Herrero José Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Quiroga Jorge Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Prieto Jesus Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Sangro Bruno Liver Unit, Clinica Universitaria de Navarra, Pamplona, Spain aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1964-1971 1068-9265 18:7<1964 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer